METALATED AROMATIC CARBOXYLIC-ACIDS - IMPROVED SYNTHESIS OF SDZ HUL412

被引：4

作者：

AMEDIO, JC

SUNAY, UB

REPIC, O

机构：

[1] Chemical Research & Development, Technical R & D, Sandoz Research Institute, Sandoz Pharmaceutical Corporation, East Hanover, New Jersey 07936

来源：

SYNTHETIC COMMUNICATIONS | 1995年 / 25卷 / 05期

关键词：

D O I：

10.1080/00397919508011404

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of aryl methyl ester 2 is described utilizing a metalation-condensation and a metalation-alkylation sequence starting from the dianion of p-toluic acid generated in an aprotic solvent medium.

引用

页码：667 / 680

页数：14

共 16 条

[1]

ABDEL RM, 1968, J CHEM UAR, V11, P401

[2] OXIDATIVE COUPLING THE TOLUIC ACID DIANION SYSTEM [J].

BELLETIRE, JL ;

SPLETZER, EG .

SYNTHETIC COMMUNICATIONS, 1986, 16 (05) :575-584

[3] A CONVENIENT SYNTHESIS OF 1,N-BIS-[4-CHLOROMETHYLPHENYL]ALKANES [J].

BUTCHER, JA ;

HINZ, HR ;

PARSONS, EJ ;

PEYSER, J .

TETRAHEDRON LETTERS, 1984, 25 (48) :5481-5482

[4]

CHEON SH, 1989, Patent No. 338993

[5]

CHEON SH, 1989, Patent No. 341213

[6]

Creger P. L., 1970, J AM CHEM SOC, V92, P1396, DOI DOI 10.1021/JA00708A048

[7]

GARZIO A, 1981, Patent No. 4273931

[8]

HANDLEY DA, 1988, J PHARMACOL EXP THER, V247, P617

[9] PREVENTION OF NON-SPECIFIC AIRWAY HYPERREACTIVITY AFTER ALLERGEN CHALLENGE IN GUINEA-PIGS BY THE PAF RECEPTOR ANTAGONIST SDZ 64-412 [J].

HAVILL, AM ;

VANVALEN, RG ;

HANDLEY, DA .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (02) :396-400

[10]

HOULIHAN W, 1990, Patent No. 4910206

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