INHIBITION BY SODIUM-NITROPRUSSIDE OF THE EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN RAT NEUTROPHILS

被引：39

作者：

MARIOTTO, S

CUZZOLIN, L

ADAMI, A

DELSOLDATO, P

SUZUKI, H

BENONI, G

机构：

[1] UNIV VERONA,IST CHIM BIOL,I-37100 VERONA,ITALY

[2] UNIV VERONA,IST FARMACOL,I-37100 VERONA,ITALY

[3] PHARMACEUT DISCOVERY SERV,MILAN,ITALY

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1995年 / 114卷 / 06期

关键词：

NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SODIUM NITROPRUSSIDE; NEUTROPHIL; NITRITE NITRATE;

D O I：

10.1111/j.1476-5381.1995.tb13320.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A well-known nitric oxide (NO)-releasing compound, sodium nitroprusside (SNP), decreases in a dose-dependent manner NO synthase (NOS) activity induced in rat neutrophils by treatment with lipopolysaccharide (LPS). This inhibitory action of SNP seems not to be due to its direct effect on the enzyme activity. The strong nitrosonium ion (NO+) character of SNP could be responsible for its inhibition of NOS induction in neutrophils.

引用

页码：1105 / 1106

页数：2

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