DELETION-6Q IN 3 CASES OF MIXED-TYPE LIPOSARCOMA IN ADDITION TO T(12-16)(Q13-P11)

被引：16

作者：

ALTUNGOZ, O

MELONI, AM

PEIER, A

ZALUPSKI, M

SPANIER, S

BROOKS, JSJ

SANDBERG, AA

机构：

[1] SW BIOMED RES INST & GENETRIX INC,CTR CANC,SCOTTSDALE,AZ 85251

[2] WAYNE STATE UNIV,HARPER HOSP,SCH MED,DIV HEMATOL ONCOL,DETROIT,MI 48201

[3] UNIV FLORIDA,COLL MED,DEPT ORTHOPED,GAINESVILLE,FL

[4] ROSWELL PK CANC INST,BUFFALO,NY

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 79卷 / 02期

关键词：

D O I：

10.1016/0165-4608(94)00180-J

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the cytogenetic findings in three mixed liposarcoma following short-term cultures. During the course of cytogenetic investigation of various types of liposarcomas, we observed an interstitial deletion of the long arm of chromosome 6 together with the translocation (12;16) (q13;p11) in three tumors. Translocation (12;16) is associated with myxoid and mixed (myxoid/round cell) liposarcomas, although deletion of chromosome 6 has been observed in only a few of these tumors. Our findings suggest that del(6), as an additional change in myxoid liposarcoma, is probably related to tumor progression.

引用

页码：104 / 110

页数：7

共 36 条

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