BILIARY AND URINARY-EXCRETION OF IOPANOIC ACID - PHARMACOKINETICS, INFLUENCE OF BILE-SALTS, AND CHOLERETIC EFFECT - EXPERIMENTAL-STUDY IN BILE-FISTULA DOGS

The biliary and urinary excretion and the chloleretic effect of iopanoic acid (Telepaque) were studied in nonanesthetized bile-fistula dogs using a stepwise increase of infusion rates of iopanoic acid and a constant infusion of sodium taurocholate at a rate of either 0.5 or 2.0 .mu.moles/min per kg. The maximum rate of bile excretion (0.671 .mu.moles/min per kg) when taurocholate was infused at the lower rate nearly doubled (1.325 .mu.moles/min per kg) when given at the higher rate. Maximum biliary concentrations of iopanoic acid at both rates of taurocholate infusion (70-77 .mu.moles/ml) were almost double the maximum concentration previously determined for iodipamide (Cholografin) (42 .mu.moles/ml).