5-ALPHA-REDUCTASE ACTIVITY IN POLYCYSTIC OVARY SYNDROME

被引：158

作者：

STEWART, PM

BEASTALL, GH

SHACKLETON, CHL

EDWARDS, CRW

机构：

[1] WESTERN GEN HOSP, DEPT MED, EDINBURGH EH4 2XU, MIDLOTHIAN, SCOTLAND

[2] CHILDRENS HOSP MED CTR NO CALIF, OAKLAND, CA 94609 USA

[3] GLASGOW ROYAL INFIRM, GLASGOW G4 0SF, SCOTLAND

来源：

LANCET | 1990年 / 335卷 / 8687期

关键词：

D O I：

10.1016/0140-6736(90)90664-Q

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

11 patients with polycystic ovary syndrome (hirsutism and oligomenorrhoea), but with no deficiency of 21 -hydroxylase or 3β-hydroxysteroid dehydrogenase, had abnormal cortisol metabolism. The high ratio of 5α to 5β cortisol metabolites in the urine is consistent with enhanced activity of 5α-reductase. Urinary total cortisol metabolites were higher in patients than controls. Increased 5α-reductase activity in liver and skin enhances hepatic cortisol metabolism at the expense of androgen excess and may be the underlying abnormality in polycystic ovary syndrome. © 1990.

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收藏

页码：431 / 433

页数：3

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