THE ROLE OF NEUROPEPTIDE-Y IN CARDIOVASCULAR REGULATION

被引：137

作者：

WALKER, P

GROUZMANN, E

BURNIER, M

WAEBER, B

机构：

[1] Research Associates Centre Hospitalier Universitaire Vaudois

[2] Centre Hositalier Universitaire Vaudois

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1991年 / 12卷 / 03期

关键词：

D O I：

10.1016/0165-6147(91)90518-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neuropeptide Y (NPY) is a 36 amino acid peptide present in the brain, the adrenal medulla and peripheral sympathetic nerves. The localization and mode of release of NPY led to the proposal that this peptide plays an important role in modulating the contribution of the sympathetic nervous system to blood pressure control. In this paper Bernard Waeber and colleagues review the current knowledge about the mechanisms involved in NPY signal transduction and the different mechanisms whereby NPY, released by the peripheral nervous system, may influence vascular tone and cardiac function.

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页码：111 / 115

页数：5

相关论文

共 43 条

[1] Y1 RECEPTORS FOR NEUROPEPTIDE-Y ARE COUPLED TO MOBILIZATION OF INTRACELLULAR CALCIUM AND INHIBITION OF ADENYLATE-CYCLASE [J].

AAKERLUND, L ;

GETHER, U ;

FUHLENDORFF, J ;

SCHWARTZ, TW ;

THASTRUP, O .

FEBS LETTERS, 1990, 260 (01) :73-78

[2] POTENTIATION BY NEUROPEPTIDE-Y OF VASOCONSTRICTION IN RAT RESISTANCE ARTERIES [J].

ANDRIANTSITOHAINA, R ;

STOCLET, JC .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 95 (02) :419-428

[3] ENHANCEMENT BY NEUROPEPTIDE-Y (NPY) OF THE DIHYDROPYRIDINE-SENSITIVE COMPONENT OF THE RESPONSE TO ALPHA-1-ADRENOCEPTOR STIMULATION IN RAT ISOLATED MESENTERIC ARTERIOLES [J].

ANDRIANTSITOHAINA, R ;

STOCLET, JC .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (02) :389-395

[4] CHARACTERIZATION OF NEUROPEPTIDE-Y BINDING-SITES IN RAT CARDIAC VENTRICULAR MEMBRANES [J].

BALASUBRAMANIAM, A ;

SHERIFF, S ;

RIGEL, DF ;

FISCHER, JE .

PEPTIDES, 1990, 11 (03) :545-550

[5] NEUROPEPTIDE-Y IN THE SYMPATHETIC CONTROL OF BLOOD-PRESSURE IN HYPERTENSIVE SUBJECTS [J].

CHALMERS, J ;

MORRIS, M ;

KAPOOR, V ;

CAIN, M ;

ELLIOTT, J ;

RUSSELL, A ;

PILOWSKY, P ;

MINSON, J ;

WEST, M ;

WING, L .

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1989, 11 :59-66

[6]

CLARKE JG, 1987, LANCET, V1, P1057

[7] NEUROPEPTIDE-Y (NPY) - ENHANCEMENT OF BLOOD-PRESSURE INCREASE UPON ALPHA-ADRENOCEPTOR ACTIVATION AND DIRECT PRESSOR EFFECTS IN PITHED RATS [J].

DAHLOF, C ;

DAHLOF, P ;

LUNDBERG, JM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 109 (02) :289-292

[8] NEUROPEPTIDE-Y MODULATES ADRENERGIC NEUROTRANSMISSION BY AN ENDOTHELIUM DEPENDENT MECHANISM [J].

DALY, RN ;

HIEBLE, JP .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 138 (03) :445-446

[9] MARKEDLY REDUCED BLOOD-PRESSURE RESPONSIVENESS IN ENDOTOXEMIC RATS - REVERSAL BY NEUROPEPTIDE-Y [J].

EVEQUOZ, D ;

WAEBER, B ;

CORDER, R ;

NUSSBERGER, J ;

GAILLARD, R ;

BRUNNER, HR .

LIFE SCIENCES, 1987, 41 (23) :2573-2580

[10] NEUROPEPTIDE-Y PREVENTS THE BLOOD-PRESSURE FALL INDUCED BY ENDOTOXIN IN CONSCIOUS RATS WITH ADRENAL MEDULLECTOMY [J].

EVEQUOZ, D ;

WAEBER, B ;

AUBERT, JF ;

FLUCKIGER, JP ;

NUSSBERGER, J ;

BRUNNER, HR .

CIRCULATION RESEARCH, 1988, 62 (01) :25-30

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