DISPLACEMENT OF THE EQUILIBRIUM IN LIPASE CATALYZED TRANSESTERIFICATION IN ETHYL OCTANOATE BY CONTINOUS EVAPORATION OF ETHANOL

被引：24

作者：

OHRNER, N

MARTINELLE, M

MATTSON, A

NORIN, T

HULT, K

机构：

[1] ROYAL INST TECHNOL,DEPT BIOCHEM & BIOTECHNOL,S-10044 STOCKHOLM 70,SWEDEN

[2] ROYAL INST TECHNOL,DEPT ORGAN CHEM,S-10044 STOCKHOLM 70,SWEDEN

来源：

BIOTECHNOLOGY LETTERS | 1992年 / 14卷 / 04期

关键词：

D O I：

10.1007/BF01022321

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A simple method to overcome low equilibrium conversion in lipase catalysed resolution of alcohols by transesterification was developed. Ethyl octanoate was used as acyl donor as well as solvent and the reaction equilibrium was shifted by applying reduced pressure, forcing the co-product ethanol to evaporate during the reaction. Using a lipase from Candida antarctica 2-octanol, 1-phenyl ethanol, 1-cyclohexyl ethanol and trans-2-methylcyclohexanol were resolved in good optical and chemical yields.

引用

页码：263 / 268

页数：6

共 15 条

[1]

ADELHORST K, 1990, SYNTHESIS-STUTTGART, V2, P112

[2] IMMUNIZATION OF LIPASE AGAINST ACETALDEHYDE EMERGING IN ACYL TRANSFER-REACTIONS FROM VINYL-ACETATE [J].