AMLODIPINE-INDUCED GINGIVAL OVERGROWTH

被引：47

作者：

SEYMOUR, RA ^{[1
]}

ELLIS, JS ^{[1
]}

THOMASON, JM ^{[1
]}

MONKMAN, S ^{[1
]}

IDLE, JR ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT PHARMACOL SCI,NEWCASTLE TYNE NE2 4BW,ENGLAND

来源：

JOURNAL OF CLINICAL PERIODONTOLOGY | 1994年 / 21卷 / 04期

关键词：

AMLODIPINE; DIHYDROPYRIDINES; CALCIUM CHANNEL BLOCKERS; GINGIVAL OVERGROWTH;

D O I：

10.1111/j.1600-051X.1994.tb00318.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Amlodipine is a calcium channel blocker used in the management of angina and hypertension. We report 3 cases of gingival overgrowth in adult dentate patients associated with chronic usage of this drug. Gingival changes occurred within 3 months of dosage and appeared to be compounded by the patient's existing periodontal condition. In all 3 patients, there was sequestration of amlodipine in their crevicular fluid. The significance of this finding in relation to the pathogenesis of this unwanted effect remains to be elucidated.

引用

页码：281 / 283

页数：3

共 14 条

[1] THE PHARMACOKINETIC PROFILE OF AMLODIPINE [J].

ABERNETHY, DR .

AMERICAN HEART JOURNAL, 1989, 118 (05) :1100-1103

[2]

AINAMO J, 1975, INT DENT J, V25, P229

[3] GINGIVAL HYPERPLASIA CAUSED BY NIFEDIPINE - HISTOPATHOLOGIC FINDINGS [J].

BARAK, S ;

ENGELBERG, IS ;

HISS, J .

JOURNAL OF PERIODONTOLOGY, 1987, 58 (09) :639-642

[4] THE INCIDENCE AND SEVERITY OF NIFEDIPINE-INDUCED GINGIVAL OVERGROWTH [J].

BARCLAY, S ;

THOMASON, JM ;

IDLE, JR ;

SEYMOUR, RA .

JOURNAL OF CLINICAL PERIODONTOLOGY, 1992, 19 (05) :311-314

[5] NITRENDIPINE-INDUCED GINGIVAL HYPERPLASIA - 1ST CASE-REPORT [J].

BROWN, RS ;

SEIN, P ;

CORIO, R ;

BOTTOMLEY, WK .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1990, 70 (05) :593-596

[6] GINGIVAL SEQUESTRATION OF NIFEDIPINE IN NIFEDIPINE-INDUCED GINGIVAL OVERGROWTH [J].

ELLIS, JS ;

SEYMOUR, RA ;

MONKMAN, SC ;

IDLE, JR .

LANCET, 1992, 339 (8806) :1382-1383

[7] NIFEDIPINE-INDUCED GINGIVAL OVERGROWTH - REPORT OF A CASE TREATED BY CONTROLLING PLAQUE [J].

HANCOCK, RH ;

SWAN, RH .

JOURNAL OF CLINICAL PERIODONTOLOGY, 1992, 19 (01) :12-14

[8]

HEIJL L, 1988, J PERIODONTOL, V60, P104

[9] FELODIPINE-INDUCED GINGIVAL HYPERPLASIA - A CLINICAL AND HISTOLOGIC-STUDY [J].

LOMBARDI, T ;

FIOREDONNO, G ;

BELSER, U ;

DIFELICE, R .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1991, 20 (02) :89-92

[10] INCIDENCE OF VERAPAMIL-INDUCED GINGIVAL HYPERPLASIA IN A DENTAL POPULATION [J].

MILLER, CS ;

DAMM, DD .

JOURNAL OF PERIODONTOLOGY, 1992, 63 (05) :453-456

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