THE ANTIOXIDANT ACTION OF SYNTHETIC ESTROGENS INVOLVES DECREASED MEMBRANE FLUIDITY - RELEVANCE TO THEIR POTENTIAL USE AS ANTICANCER AND CARDIOPROTECTIVE AGENTS COMPARED TO TAMOXIFEN

被引:29
作者
WISEMAN, H
QUINN, P
机构
[1] UNIV LONDON KINGS COLL, PHARMACOL GRP, LONDON SW3 6LX, ENGLAND
[2] UNIV LONDON KINGS COLL, DIV LIFE SCI, LONDON W8 7AH, ENGLAND
关键词
SYNTHETIC ESTROGENS; ANTIOXIDANT; TAMOXIFEN; ANTICANCER ACTION; CARDIOPROTECTION; MEMBRANE FLUIDITY;
D O I
10.3109/10715769409056569
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthetic oestrogens diethylstilboestrol, hexoestrol and 17 alpha-ethynyloestradiol are known to be good antioxidants, and we now report that they decrease membrane fluidity, in ox-brain phospholipid liposomes. The order of effectiveness was diethylstilboestrol > hexoestrol > 17 alpha-ethynyloestradiol and a good positive correlation was demonstrated between decreased membrane fluidity and antioxidant ability (measured as inhibition of liposomal lipid peroxidation: correlation coefficient, r = 0.99). This ability of diethylstilboestrol, hexoestrol and 17 alpha-ethynyloestradiol to decrease membrane fluidity is suggested, therefore, to be the mechanism of their antioxidant action. The membrane-modulating antioxidant action of these synthetic oestrogens is compared to that of tamoxifen and their potential use as anticancer and cardioprotective agents is discussed.
引用
收藏
页码:187 / 194
页数:8
相关论文
共 39 条
[1]  
BAGGS RB, 1991, CANCER RES, V51, P3311
[2]   PHASE-SEPARATION OF LIQUID-MIXTURES UNDER SHEAR-FLOW [J].
BAUMBERGER, T ;
PERROT, F ;
BEYSENS, D .
PHASE TRANSITIONS, 1991, 31 (1-4) :251-259
[3]  
BORSTEIN J, 1988, OBSTET GYNECOL, V43, P15
[4]   TAMOXIFEN FOR THE PRIMARY PREVENTION OF BREAST-CANCER - A REVIEW AND CRITIQUE OF THE CONCEPT AND TRIAL [J].
BUSH, TL ;
HELZLSOUER, KJ .
EPIDEMIOLOGIC REVIEWS, 1993, 15 (01) :233-243
[5]  
BUTTA A, 1992, CANCER RES, V52, P4261
[6]  
CHLEBOWSKI RT, 1993, CANCER, V72, P1032, DOI 10.1002/1097-0142(19930801)72:3+<1032::AID-CNCR2820721315>3.0.CO
[7]  
2-O
[8]   CLINICAL AND RADIOGRAPHIC RESPONSE IN A MINORITY OF PATIENTS WITH RECURRENT MALIGNANT GLIOMAS TREATED WITH HIGH-DOSE TAMOXIFEN [J].
COULDWELL, WT ;
WEISS, MH ;
DEGIORGIO, CM ;
WEINER, LP ;
HINTON, DR ;
EHRESMANN, GR ;
CONTI, PS ;
APUZZO, MLJ ;
KORNBLITH, P ;
DETRIBOLET, N ;
TAOA, M ;
LEVIN, VA ;
OLDFIELD, EH .
NEUROSURGERY, 1993, 32 (03) :485-490
[9]   ADJUVANT TAMOXIFEN VERSUS PLACEBO IN ELDERLY WOMEN WITH NODE-POSITIVE BREAST-CANCER - LONG-TERM FOLLOW-UP AND CAUSES OF DEATH [J].
CUMMINGS, FJ ;
GRAY, R ;
TORMEY, DC ;
DAVIS, TE ;
VOLK, H ;
HARRIS, J ;
FALKSON, G ;
BENNETT, JM .
JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (01) :29-35
[10]   THE CYCLIC AMP-MEDIATED STIMULATION OF CELL-PROLIFERATION [J].
DUMONT, JE ;
JAUNIAUX, JC ;
ROGER, PP .
TRENDS IN BIOCHEMICAL SCIENCES, 1989, 14 (02) :67-71