THE ANTIBACTERIAL ACTIVITY OF A SIDEROPHORE .3. THE ACTIVITY OF DEFEROXAMINE IN-VITRO AND ITS INFLUENCE ON THE EFFECT OF ANTIBIOTICS AGAINST ESCHERICHIA-COLI, PROTEUS-MIRABILIS AND COAGULASE-NEGATIVE STAPHYLOCOCCI

被引：10

作者：

HARTZEN, SH ^{[1
]}

FRIMODTMOLLER, N ^{[1
]}

THOMSEN, VF ^{[1
]}

机构：

[1] STATENS SERUM INST, DEPT ANTIBIOT, DK-2300 COPENHAGEN, DENMARK

来源：

APMIS | 1994年 / 102卷 / 03期

关键词：

DEFEROXAMINE; SIDEROPHORE; ANTIMICROBIAL ACTIVITY; ANTIMICROBIAL INTERACTION;

D O I：

10.1111/j.1699-0463.1994.tb04868.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The in vitro activity of deferoxamine (DFO) both per se and in combination with the reductant ascorbic acid (API) was determined against 10 E. coli strains, 5 P. mirabilis strains, and 10 coagulase-negative staphylococci. In terms of interaction, the influence of DFO on the activities of cephalothin and gentamicin was furthermore investigated against the same panel of strains employing a macrobroth dilution technique and killing-curve kinetics. The MICs of cephalothin and gentamicin were lowered for one half of the strains. Moreover, DFO prolonged the generation times of logarithmic growth phase considerably, especially when the reductant AA was present. The interactions between DFO or DFO + AA and subinhibitory concentrations of antibiotics were established by the application of growth constants, and resulted in synergy for 15 out of 25 strains with cephalothin and 9 out of 25 strains with gentamicin.

引用

页码：219 / 226

页数：8

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