THE STUDY OF ANTICARDIOLIPIN ANTIBODIES AND INTERLEUKIN-6 IN CEREBROSPINAL-FLUID AND BLOOD OF CHINESE PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS AND CENTRAL-NERVOUS-SYSTEM INVOLVEMENT

被引：21

作者：

YEH, TS ^{[1
]}

WANG, CR ^{[1
]}

JENG, GW ^{[1
]}

LEE, GL ^{[1
]}

CHEN, MY ^{[1
]}

WANG, GR ^{[1
]}

LIN, KT ^{[1
]}

CHUANG, CY ^{[1
]}

CHEN, CY ^{[1
]}

机构：

[1] NATL TAIWAN UNIV HOSP,COLL MED,DEPT INTERNAL MED,RHEUMATOL SECT,TAIPEI 100,TAIWAN

来源：

AUTOIMMUNITY | 1994年 / 18卷 / 03期

关键词：

ANTICARDIOLIPIN ANTIBODY; INTERLEUKIN-6; SYSTEMIC LUPUS ERYTHEMATOSUS;

D O I：

10.3109/08916939409007993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anticardiolipin (ACL) antibodies and interleukin-6 (IL-6) in cerebrospinal fluid (CSF) may be involved in the mechanism of lupus patients with central nervous system (CNS) involvement. ACL antibodies of 3 isotypes and IL-6 were measured in paired CSF and serum samples from 14 lupus patients with CNS involvement, 5 lupus patients without CNS involvement and 7 patients with non-inflammatory neurological diseases. ACL antibodies, IgG and IgM isotypes, and IL-6 were significantly increased in CSF from lupus patients with CNS involvement as compared with other 2 groups of patients. Both ACL antibodies and IL-6 decreased after neurological activity subsided. These results suggest increased ACL antibodies and IL-6 in CSF are involved in immune responses within CNS in lupus patients. Quantitation of CSF ACL antibodies may be helpful in evaluating neurological activity of lupus patients with CNS involvement.

引用

页码：169 / 175

页数：7

共 29 条

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