FLUOROALUMINATE MIMICS AGONIST APPLICATION IN SINGLE-RAT HEPATOCYTES

被引：16

作者：

WOODS, NM

DIXON, CJ

CUTHBERTSON, KSR

COBBOLD, PH

机构：

[1] Department of Human Anatomy, University of Liverpool, Liverpool L69 3BX

来源：

BIOCHEMICAL JOURNAL | 1990年 / 265卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1042/bj2650613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Single rat hepatocytes microinjected with the photoprotein aequorin were stimulated with glycogenolytic agonists or low concentrations of fluoroaluminate. Both protocols resulted in the generation of oscillations in cytolosic free Ca2+ levels from a resting value of approx. 200 nM and peaking at over 600 nM. However, oscillations induced by receptor-dependent agonists were more regular in both frequency and time course than those induced by direct activation of G-proteins. The role of G-proteins in the generation of repetitive free Ca2+ oscillations is discussed.

引用

页码：613 / 615

页数：3

共 16 条

[1] FUNCTIONALLY DISTINCT G-PROTEINS SELECTIVELY COUPLE DIFFERENT RECEPTORS TO PL HYDROLYSIS IN THE SAME CELL [J].