VIRAL MYOCARDITIS

被引：8

作者：

BURKE, M ^{[1
]}

机构：

[1] ST GEORGE HOSP,SCH MED,DEPT HISTOPATHOL,LONDON,ENGLAND

来源：

HISTOPATHOLOGY | 1990年 / 17卷 / 03期

关键词：

idiopathic dilated cardiomyopathy; pathogenesis; viral myocarditis;

D O I：

10.1111/j.1365-2559.1990.tb00707.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Evidence suggests that in susceptible individuals lymphocytic myocarditis is a virus‐induced autoimmune disease which may progress to dilated cardiomyopathy. Its biopsy pathology, the application of the ‘Dallas’ criteria for diagnosis and the role of immunohistochemistry are discussed. The potential role for in situ hybridization in the detection of viral genomes is referred to. Pathogenesis may be related to persistence of viral RNA in tissues and may involve both cellular and humoral immune mechanisms. The effect may manifest itself at cellular level with myocytolysis or at sub‐cellular level with interference in energy production, giving rise to considerable functional deficit with few morphological changes. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：193 / 200

页数：8

共 52 条

[1] IMMUNOSUPPRESSIVE THERAPY OF MYOCARDIAL INFLAMMATORY DISEASE - INITIAL EXPERIENCE AND FUTURE TRIALS TO DEFINE INDICATIONS FOR THERAPY [J].