INTERFERENCE WITH UTERINE BLOOD MOW BY CLOMIPHENE CITRATE IN WOMEN WITH UNEXPLAINED INFERTILITY

被引:35
作者
HSU, CC
KUO, HC
WANG, ST
HUANG, KE
机构
[1] NATL CHENG KUNG UNIV,COLL MED,DEPT PUBL HLTH,TAINAN,TAIWAN
[2] KAO HSIUNG MUNICIPAL MATERNAL CHILDRENS HOSP,KAOHSIUNG,TAIWAN
关键词
D O I
10.1016/0029-7844(95)00287-2
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To investigate the effect of clomiphene citrate on the uterine blood now in women with unexplained infertility. Methods: Twenty-one women who had normal uterine blood now (pulsatility index [PI] less than 3 from the LH peak to the middle luteal phase of a natural ovulatory cycle) were enrolled in this study. Patients were given clomiphene citrate (100 mg/day) from days 5-9 of the next ovulatory cycle. The PI values measured in the natural and clomiphene citrate-treated cycles were compared using repeated measures analysis of variance. Their correlations with the estradiol (E2) and progesterone concentrations in the treatment cycle were calculated using the Pearson correlation coefficient. Result: In the natural cycles of those with normal uterine blood now, the highest impedance of uterine blood now was detected at the late follicular phase, then blood flow increased during the luteal phase. In the clomiphene citrate-treated cycles, a statistically significant decrease in uterine blood flow also occurred during the early luteal phase (P < .05). No significant correlation of E2 or progesterone serum concentrations with PI values of the uterine artery could be found in either natural or clomiphene citrate-treated cycles. Conclusion: The use of clomiphene citrate decreases the uterine blood flow during the early luteal phase, a periimplantation stage.
引用
收藏
页码:917 / 921
页数:5
相关论文
共 20 条
[1]   CLOMIPHENE CITRATE-INITIATED OVULATION - A CLINICAL UPDATE [J].
ADASHI, EY .
SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY, 1986, 4 (03) :255-276
[2]   EFFECTS OF CLOMIPHENE CITRATE ON CYTOSOLIC ESTRADIOL AND PROGESTERONE-RECEPTOR CONCENTRATIONS IN SECRETORY ENDOMETRIUM [J].
AKSEL, S ;
SARACOGLU, OF ;
YEOMAN, RR ;
WIEBE, RH .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1986, 155 (06) :1219-1223
[3]   DOPPLER ULTRASOUND STUDIES OF THE UTERINE ARTERIES IN SPONTANEOUS AND IVF STIMULATED OVARIAN CYCLES [J].
BATTAGLIA, C ;
LAROCCA, E ;
LANZANI, A ;
VALENTINI, M ;
GENAZZANI, AR .
GYNECOLOGICAL ENDOCRINOLOGY, 1990, 4 (04) :245-250
[4]  
Brenner R. M., 1994, PHYSL REPRODUCTION, V1, P541
[5]   INDUCTION OF LUTEAL PHASE DEFECT WITH CLOMIPHENE CITRATE [J].
COOK, CL ;
SCHROEDER, JA ;
YUSSMAN, MA ;
SANFILIPPO, JS .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1984, 149 (06) :613-616
[6]   INFERTILITY IN WOMEN WITH APPARENTLY OVULATORY CYCLES .2. EFFECTS OF CLOMIPHENE TREATMENT ON PROFILES OF GONADOTROPIN AND SEX STEROID-HORMONES IN PERIPHERAL PLASMA [J].
DODSON, KS ;
MACNAUGHTON, MC ;
COUTTS, JRT .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1975, 82 (08) :625-633
[7]  
EDEN JA, 1989, OBSTET GYNECOL, V73, P187
[8]   ENDOMETRIAL BLOOD-FLOW MEASURED BY XE-133 CLEARANCE IN WOMEN WITH NORMAL MENSTRUAL CYCLES AND DYSFUNCTIONAL UTERINE BLEEDING [J].
FRASER, IS ;
MCCARRON, G ;
HUTTON, B ;
MACEY, D .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1987, 156 (01) :158-166
[9]   PULSATILITY INDEX OF UTERINE ARTERY IN PREGNANT AND NONPREGNANT WOMEN [J].
FUJINO, Y ;
ITO, F ;
MATUOKA, I ;
KOJIMA, T ;
KOH, B ;
OGITA, S .
HUMAN REPRODUCTION, 1993, 8 (07) :1126-1128
[10]   DECREASED UTERINE PERFUSION - A CAUSE OF INFERTILITY [J].
GOSWAMY, RK ;
WILLIAMS, G ;
STEPTOE, PC .
HUMAN REPRODUCTION, 1988, 3 (08) :955-959