FORMATION OF K-REGION EPOXIDES AS HEPATIC MICROSOMAL METABOLITES OF -METHYLBENZ[A]ANTHRACENE AND 7,12-DIMETHYLBENZ[A]ANTHRACENE AND THEIR 7-HYDROXYMETHYL DERIVATIVES

被引：63

作者：

KEYSELL, GR ^{[1
]}

BOOTH, J ^{[1
]}

GROVER, PL ^{[1
]}

HEWER, A ^{[1
]}

SIMS, P ^{[1
]}

机构：

[1] ROY CANC HOSP, INST CANC RES, CHESTER BEATTY RES INST, FULHAM RD, LONDON SW3 6JB, ENGLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1973年 / 22卷 / 22期

关键词：

D O I：

10.1016/0006-2952(73)90152-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：2853 / 2867

页数：15

共 38 条

[1] EPOXIDES OF CARCINOGENIC POLYCYCLIC HYDROCARBONS ARE FRAMESHIFT MUTAGENS
AMES, BN
SIMS, P
GROVER, PL
[J]. SCIENCE, 1972, 176 (4030) : 47 - &
[2] FORMATION OF GLUTATHIONE CONJUGATES AS METABOLITES OF 7,12-DIMETHYLBENZ-[A]ANTHRACENE BY RAT-LIVER HOMOGENATES
BOOTH, J
KEYSELL, GR
SIMS, P
[J]. BIOCHEMICAL PHARMACOLOGY, 1973, 22 (14) : 1781 - 1791
[3] METABOLISM OF POLYCYCLIC COMPOUNDS - METABOLISM OF 7,12-DIMETHYLBENZ(A)ANTHRACENE BY RAT-LIVER HOMOGENATES
BOYLAND, E
SIMS, P
[J]. BIOCHEMICAL JOURNAL, 1965, 95 (03) : 780 - &
[4] INDUCTION OF ADRENAL DAMAGE AND CANCER WITH METABOLITES OF 7,12-DIMETHYLBENZ(A)ANTHRACENE
BOYLAND, E
SIMS, P
HUGGINS, C
[J]. NATURE, 1965, 207 (4999) : 816 - &
[5] EFFECT OF PRETREATMENT WITH ADRENAL-PROTECTING COMPOUNDS ON METABOLISM OF 7,12-DIMETHYLBENZ[A]ANTHRACENE AND RELATED COMPOUNDS BY RAT-LIVER HOMOGENATES
BOYLAND, E
SIMS, P
[J]. BIOCHEMICAL JOURNAL, 1967, 104 (02) : 394 - +
[6] AN ENYZYME CATALYSING CONJUGATION OF EPOXIDES WITH GLUTATHIONE
BOYLAND, E
WILLIAMS, K
[J]. BIOCHEMICAL JOURNAL, 1965, 94 (01) : 190 - &
[7] BOYLAND E, 1950, S BIOCHEM SOC, V5, P40
[8] MUTAGENICITY OF EPOXIDES OF POLYCYCLIC HYDROCARBONS CORRELATES WITH CARCINOGENICITY OF PARENT HYDROCARBONS
COOKSON, MJ
SIMS, P
GROVER, PL
[J]. NATURE-NEW BIOLOGY, 1971, 234 (49): : 186 - &
[9] FLESHER JW, 1971, CANCER RES, V31, P1951
[10] SYNTHESES OF METABOLITES OF 7,12-DIMETHYLBENZ[A]ANTHRACENE . 4-HYDROXY-7,12-DIMETHYLBENZ[A]ANTHRACENE 7-HYDROXYMETHYL-12-METHYLBENZ[A]ANTHRACENE THEIR METHYL ETHERS AND ACETOXY DERIVATIVES
FLESHER, JW
SOEDIGDO, S
KELLEY, DR
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (05) : 932 - &

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