The ASTEROID trial: coronary plaque regression with high-dose statin therapy

被引：24

作者：

Chhatriwalla, Adnan K. ^{[1
]}

Nicholls, Stephen J. ^{[2
]}

Nissen, Steven E. ^{[1
]}

机构：

[1] Cleveland Clin, Desk F-15, Cleveland, OH 44195 USA

[2] Cleveland Clin, Ctr Cardiovasc Diagnost & Prevent, Dept Cardiovasc Med JJ65, Cleveland, OH 44195 USA

来源：

FUTURE CARDIOLOGY | 2006年 / 2卷 / 06期

关键词：

atherosclerosis; cholesterol; coronary artery disease; HMG Co-A reductase inhibitors; intravascular ultrasound; low-density lipoprotein cholesterol; statins;

D O I：

10.2217/14796678.2.6.651

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A Study To Evaluate the effect of Rosuvastatin On Intravascular ultrasound-Derived coronary atheroma burden (ASTEROID) investigated the impact of high-dose rosuvastatin therapy on the rate of atheroma progression in patients with coronary artery disease. Serial intravascular ultrasound (IVUS) was performed in 349 patients at baseline and following 24 months of therapy with rosuvastatin 40 mg/day. Rosuvastatin therapy lowered low-density lipoprotein cholesterol to 60.8 mg/dl and raised high-density lipoprotein cholesterol by 14.7%. This was associated with a significant reduction in all IVUS measures of atheroma burden. These results suggest that intensive modification of lipid levels with high-dose statin therapy can promote atheroma regression. Further studies will be required to determine whether this benefit is associated with a reduction in clinical events.

引用

页码：651 / 654

页数：4

共 16 条

[1] CORONARY ANGIOGRAPHIC CHANGES WITH LOVASTATIN THERAPY - THE MONITORED ATHEROSCLEROSIS REGRESSION STUDY (MARS) [J].

BLANKENHORN, DH ;

AZEN, SP ;

KRAMSCH, DM ;

MACK, WJ ;

CASHINHEMPHILL, L ;

HODIS, HN ;

DEBOER, LWV ;

MAHRER, PR ;

MASTELLER, MJ ;

VAILAS, LI ;

ALAUPOVIC, P ;

HIRSCH, LJ .

ANNALS OF INTERNAL MEDICINE, 1993, 119 (10) :969-976

[2] Intensive versus moderate lipid lowering with statins after acute coronary syndromes [J].

Cannon, CP ;

Braunwald, E ;

McCabe, CH ;

Rader, DJ ;

Rouleau, JL ;

Belder, R ;

Joyal, SV ;

Hill, KA ;

Pfeffer, MA ;

Skene, AM .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (15) :1495-1504

[3] Comparison of effects on low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with rosuvastatin versus atorvastatin in patients with type IIa or IIb hypercholesterolemia [J].

Davidson, M ;

Ma, P ;

Stein, EA ;

Gotto, AM ;

Raza, A ;

Chitra, R ;

Hutchinson, H .

AMERICAN JOURNAL OF CARDIOLOGY, 2002, 89 (03) :268-275

[4] Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels - Results of AFCAPS/TexCAPS [J].

Downs, JR ;

Clearfield, M ;

Weis, S ;

Whitney, E ;

Shapiro, DR ;

Beere, PA ;

Langendorfer, A ;

Stein, EA ;

Kruyer, W ;

Gotto, AM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (20) :1615-1622

[5] Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines [J].

Grundy, SM ;

Cleeman, JI ;

Merz, CNB ;

Brewer, HB ;

Clark, LT ;

Hunninghake, DB ;

Pasternak, RC ;

Smith, SC ;

Stone, NJ .

CIRCULATION, 2004, 110 (02) :227-239

[6] Radiolabeled native low-density lipoprotein injected into patients with carotid stenosis accumulates in macrophages of atherosclerotic plaque - Effect of vitamin E supplementation [J].

Iuliano, L ;

Mauriello, A ;

Sbarigia, E ;

Spagnoli, LG ;

Violi, F .

CIRCULATION, 2000, 101 (11) :1249-1254

[7] Intensive lipid lowering with atorvastatin in patients with stable coronary disease [J].

LaRosa, JC ;

Grundy, SM ;

Waters, DD ;

Shear, C ;

Barter, P ;

Fruchart, J ;

Gotto, AM ;

Greten, H ;

Kastelein, JJP ;

Shepherd, J ;

Wenger, NK .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (14) :1425-1435

[8] Effect of very high-intensity statin therapy on regression of coronary atherosclerosis - The ASTEROID trial [J].

Nissen, SE ;

Nicholls, SJ ;

Sipahi, I ;

Libby, P ;

Raichlen, JS ;

Ballantyne, CM ;

Davignon, J ;

Erbel, R ;

Fruchart, JC ;

Tardif, JC ;

Schoenhagen, P ;

Crowe, T ;

Cain, V ;

Wolski, K ;

Goormastic, M ;

Tuzcu, EM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (13) :1556-1565

[9] Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis - A randomized controlled trial [J].

Nissen, SE ;

Tuzcu, EM ;

Schoenhagen, P ;

Brown, BG ;

Ganz, P ;

Vogel, RA ;

Crowe, T ;

Howard, G ;

Cooper, CJ ;

Brodie, B ;

Grines, CL ;

DeMaria, AN .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (09) :1071-1080

[10] Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes - A randomized controlled trial [J].

Nissen, SE ;

Tsunoda, T ;

Tuzcu, EM ;

Schoenhagen, P ;

Cooper, CJ ;

Yasin, M ;

Eaton, GM ;

Lauer, MA ;

Sheldon, WS ;

Grines, CL ;

Halpern, S ;

Crowe, T ;

Blankenship, JC ;

Kerensky, R .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (17) :2292-2300

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