THE IGG, IGM, AND IGA ISOTYPES OF ANTI-TOPOISOMERASE-I AND ANTICENTROMERE AUTOANTIBODIES

被引:41
作者
HILDEBRANDT, S
WEINER, E
SENECAL, JL
NOELL, S
DANIELS, L
EARNSHAW, WC
ROTHFIELD, NF
机构
[1] HOSP NOTRE DAME,RHEMATOL IMMUNOL RES LAB,MONTREAL,QUEBEC,CANADA
[2] HOSP NOTRE DAME,DIV RHEMATOL,CONNECT TISSUE DIS CLIN,MONTREAL,QUEBEC,CANADA
[3] UNIV MONTREAL,SCH MED,MONTREAL H3C 3J7,QUEBEC,CANADA
[4] JOHNS HOPKINS UNIV,DEPT CELL BIOL & ANAT,BALTIMORE,MD 21218
来源
ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 05期
关键词
D O I
10.1002/art.1780330515
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We studied the expression of IgG, IgM, and IgA autoantibodies in the anti‐topoisomerase I and anticentromere immune responses by enzyme‐linked immunosorbent assay, immunoblotting, and immunofluorescence. While IgG autoantibodies were most common, IgA autoantibodies were also frequently found, but IgM autoantibodies were rare. This is the first report of IgA autoantibodies in scleroderma. Copyright © 1990 American College of Rheumatology
引用
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页码:724 / 727
页数:4
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