S-LAMININ EXPRESSION IN ADULT AND DEVELOPING RETINAE - A POTENTIAL CUE FOR PHOTORECEPTOR MORPHOGENESIS

被引:122
作者
HUNTER, DD [1 ]
MURPHY, MD [1 ]
OLSSON, CV [1 ]
BRUNKEN, WJ [1 ]
机构
[1] BOSTON COLL,DEPT BIOL,CHESTNUT HILL,MA 02167
关键词
D O I
10.1016/0896-6273(92)90269-J
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The development of the neural retina follows a stereo-typed time course that begins with an undifferentiated neuroepithelium populated by multipotential progenitor cells and ends with a highly differentiated tissue containing diverse cell types. The identities of the factors that guide this differentiation have remained elusive; a likely location for such factors, however, is the extracellular environment. Here, we show that the extracellular matrix component s-laminin is present in the neural retina, that s-laminin expression parallels the differentiation of rod photoreceptors, that photoreceptors interact with s-laminin in vitro, and that antibodies to s-laminin profoundly reduce the appearance of cells that express rhodopsin in vitro. These data suggest that s-laminin plays a role in the differentiation of the neural retina and provide evidence that the composition of the extracellular matrix may be an important determinant of retinal differentiation.
引用
收藏
页码:399 / 413
页数:15
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