MICE BEARING THE E-MU-MYC AND E-MU-PIM-1 TRANSGENES DEVELOP PRE-B-CELL LEUKEMIA PRENATALLY

被引：169

作者：

VERBEEK, S

VANLOHUIZEN, M

VANDERVALK, M

DOMEN, J

KRAAL, G

BERNS, A

机构：

[1] NETHERLANDS CANC INST,DIV MOLEC GENET,PLESMANLAAN 121,1066 CX AMSTERDAM,NETHERLANDS

[2] UNIV AMSTERDAM,DEPT BIOCHEM,1066 CX AMSTERDAM,NETHERLANDS

[3] FREE UNIV AMSTERDAM,DEPT CELL BIOL,1081 HV AMSTERDAM,NETHERLANDS

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 02期

关键词：

D O I：

10.1128/MCB.11.2.1176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previously, it has been shown that E-mu-pim-1 transgenic mice are predisposed to T-cell lymphomas, whereas E-mu-myc transgenic mice are predisposed to pre-B-cell lymphomas. Here we show that double-transgenic E-mu-myc E-mu-pim-1 mice exhibit pre-B-cell leukemia in utero. Upon transplantation into recipient mice, embryo-derived double-transgenic leukemic cells frequently progressed to highly malignant monoclonal tumors, indicating that additional (epi)genetic events had occurred during the progression of the disease.

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页码：1176 / 1179

页数：4

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