INCREASED PLASMA-LEVELS AND BLUNTED EFFECTS OF BRAIN NATRIURETIC PEPTIDE IN RATS WITH CONGESTIVE-HEART-FAILURE

被引：22

作者：

HOFFMAN, A

GROSSMAN, E

KEISER, HR

机构：

[1] National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 07期

关键词：

BRAIN NATRIURETIC PEPTIDE; ATRIAL NATRIURETIC FACTOR; CONGESTIVE HEART FAILURE; RENAL FUNCTION; RADIOIMMUNOASSAY;

D O I：

10.1093/ajh/4.7.597

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The hemodynamic and renal effects of brain natriuretic peptide (BNP) were studied in conscious rats with experimental congestive heart failure (CHF) produced by an aortocaval fistula. The peptide had potent hypotensive, diuretic, and natriuretic effects in control rats, all of which were abolished in CHF. Plasma levels of BNP increased time-dependently during the development of CHF, and were more than four-fold higher in sodium retaining rats than in control rats. The data suggest that BNP secretion from the atria is increased in CHF, and that resistance to BNP, in addition to the relative resistance to atrial natriuretic factor, may contribute to sodium retention in CHF.

引用

页码：597 / 601

页数：5

共 15 条

[1] Sudoh T., Kangawa K., Minamino N., Matsuo H., A new natriuretic peptide in porcine brain, Nature, 332, pp. 78-81, (1988)
[2] Tang C.S., Cui H., Yuan Q.X., Tang J., Hemodynamic responses to BNF in rats, Europ J Pharmacol, 159, pp. 327-328, (1989)
[3] Song D.L., Koshe K.P., Murad F., Brain natriuretic factor. Augmentation of cellular cGMP, activation of particulateguanylate cyclase and receptor binding, FEBS Lett, 232, pp. 125-129, (1988)
[4] Iwata T., Inui K., Nakao K., Et al., Effect of brain natriuretic peptide on cycline GMP accumulation in a kidney epithelial cell line, Europ J Pharmacol, 159, pp. 321-323, (1989)
[5] Saito Y., Nakao K., Itoh H., Et al., Brain natriuretic peptide is a novel cardiac hormone, Biochem Biophys Res Com-Mun, 158, pp. 360-368, (1989)
[6] Burnett J.C., Kao P.C., Hu D.C., Et al., Atrial natriuretic peptide elevation in congestive heart failure in the human, Science, 231, pp. 1145-1147, (1986)
[7] Hoffman A., Burnett J.C., Haramati A., Winaver J., Effects of atrial natriuretic factor in rats with experimental highoutput heart failure, Kidney Int, 33, pp. 656-661, (1988)
[8] Winaver J., Hoffman A., Burnett J.C., Haramati A., Hormonal determinants of sodium excretion in rats with experimental high-output heart failure, Am J Physiol, 254, pp. R776-R784, (1988)
[9] Hirata Y., Shichiri M., Emori T., Et al., Brain natriuretic peptide interacts with atrial natriuretic peptide receptorin cultured rat vascular smooth muscle cells, FEBS Lett, 238, pp. 415-418, (1988)
[10] Shirakami G., Nakao K., Yamada T., Et al., Inhibitory effect of brain natriuretic peptide on central angiotensin II stimulated pressor response in conscious rats, Neurosci Lett, 91, pp. 77-83, (1988)

← 1 2 →