ABSORPTION OF NITROGEN-DIOXIDE AND NITRIC-OXIDE BY SODA LIME

被引:18
作者
ISHIBE, T [1 ]
SATO, T [1 ]
HAYASHI, T [1 ]
KATO, N [1 ]
HATA, T [1 ]
机构
[1] TAIYO SANSO CO LTD,DIV DEV,OSAKA,JAPAN
关键词
CARBON DIOXIDE; ELIMINATION; SAFETY; EQUIPMENT; GASES NONANAESTHETIC; NITRIC OXIDE; GASES NON-ANESTHETIC; NITROGEN DIOXIDE; TOXICITY; METABOLITES;
D O I
10.1093/bja/75.3.330
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Inhaled nitric oxide (NO) is used for the treatment of pulmonary hypertension as a selective pulmonary vasodilator. However, NO is oxidized rapidly to the more toxic nitrogen dioxide (NO2). Elimination of NO2 from inspired gas is essential for safe clinical use NO. We therefore investigated the efficacy of soda lime in absorbing NO2 from NO2-containing gases. Commercially available soda limes (Soda sorb and Wake lime-A), were exposed to the following six gas mixtures containing NO and NO2 in a hypoxic carrier gas for 20 min: No, 1: NO 40 ppm; No. 2: NO 35 ppm and NO2 5 ppm; No, 3: NO 30 ppm and NO2 10 ppm; No. 4: NO 20 ppm and NO2 20 ppm; No, 5: NO 10 ppm and NO2 30 ppm; and No. 6: NO2 40 ppm. Both types of soda lime completely absorbed the NO2 in all samples when it was present (Nos 2-6). NO concentration in these gas mixtures was reduced by an amount equal to the NO2 absorbed by soda lime. NO was absorbed minimally when NO2 was not present in the mixture. Nitrite was detected from the Wako lime-A granules exposed to the test gas by the chemical analysis. These findings suggest that soda lime completely absorbs NO2 by chemical neutralization, but NO is absorbed as simultaneously absorbed NO2 only where NO and NO2 coexist. Therefore, we conclude that soda lime is useful for NO2 absorption during NO inhalation therapy but NO monitoring from a point distal to the soda lime is required for precise control of inspired NO concentration.
引用
收藏
页码:330 / 333
页数:4
相关论文
共 11 条
[1]   ENHANCED PNEUMONIA RESOLUTION BY INHALATION OF NITRIC-OXIDE [J].
BLOMQVIST, H ;
WICKERTS, CJ ;
ANDREEN, M ;
ULLBERG, U ;
ORTQVIST, A ;
FROSTELL, C .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1993, 37 (01) :110-114
[2]   SAFETY REQUIREMENT FOR USE OF INHALED NITRIC-OXIDE IN NEONATES [J].
BOUCHET, M ;
RENAUDIN, MH ;
RAVEAU, C ;
MERCIER, JC ;
DEHAN, M ;
ZUPAN, V .
LANCET, 1993, 341 (8850) :968-969
[3]   SAFETY GUIDELINES FOR USE OF NITRIC-OXIDE [J].
FOUBERT, L ;
FLEMING, B ;
LATIMER, R ;
JONAS, M ;
ODURO, A ;
BORLAND, C ;
HIGENBOTTAM, T .
LANCET, 1992, 339 (8809) :1615-1616
[4]  
ISHIBE Y, 1995, BRIT J ANAESTH, V74, P107, DOI 10.1093/bja/74.1.107
[5]   HIGHER OXIDES OF NITROGEN IN ANAESTHETIC GAS CIRCUITS [J].
KAIN, ML .
BRITISH JOURNAL OF ANAESTHESIA, 1967, 39 (05) :382-&
[6]   EFFECTS OF HUMIDITY AND TEMPERATURE ON NITROGEN-DIOXIDE FORMATION FROM NITRIC-OXIDE [J].
MIYAMOTO, K ;
AIDA, A ;
NISHIMURA, M ;
NAKANO, T ;
KAWAKAMI, Y ;
OHMORI, Y ;
ANDO, S ;
ICHIDA, T .
LANCET, 1994, 343 (8905) :1099-1100
[7]   INHALED NITRIC-OXIDE AS A CAUSE OF SELECTIVE PULMONARY VASODILATATION IN PULMONARY-HYPERTENSION [J].
PEPKEZABA, J ;
HIGENBOTTAM, TW ;
DINHXUAN, AT ;
STONE, D ;
WALLWORK, J .
LANCET, 1991, 338 (8776) :1173-1174
[8]   THE ROLE OF SODA LIME DURING ADMINISTRATION OF INHALED NITRIC-OXIDE [J].
PICKETT, JA ;
MOORS, AH ;
LATIMER, RD ;
MAHMOOD, N ;
GHOSH, S ;
ODURO, A .
BRITISH JOURNAL OF ANAESTHESIA, 1994, 72 (06) :683-685
[9]   INHALED NITRIC-OXIDE FOR THE ADULT RESPIRATORY-DISTRESS SYNDROME [J].
ROSSAINT, R ;
FALKE, KJ ;
LOPEZ, F ;
SLAMA, K ;
PISON, U ;
ZAPOL, WM .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (06) :399-405
[10]   EVALUATION OF A NEW SYSTEM FOR VENTILATORY ADMINISTRATION OF NITRIC-OXIDE [J].
STENQVIST, O ;
KJELLTOFT, B ;
LUNDIN, S .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1993, 37 (07) :687-691