PRECISE LOCALIZATION OF APHIDICOLIN-INDUCED BREAKPOINTS ON THE SHORT ARM OF HUMAN-CHROMOSOME-3

被引:51
作者
PARADEE, W
MULLINS, C
HE, ZQ
GLOVER, T
WILKE, C
OPALKA, B
SCHUTTE, J
SMITH, DI
机构
[1] WAYNE STATE UNIV,SCH MED,DEPT INTERNAL MED,DIV HEMATOL ONCOL,DETROIT,MI 48201
[2] WAYNE STATE UNIV,SCH MED,DEPT MOLEC BIOL & GENET,DETROIT,MI 48201
[3] WAYNE STATE UNIV,SCH MED,CANC BIOL TRAINING PROGRAM,DETROIT,MI 48201
[4] UNIV MICHIGAN,SCH MED,DEPT PEDIAT,ANN ARBOR,MI
[5] UNIV MICHIGAN,SCH MED,DEPT HUMAN GENET,ANN ARBOR,MI
[6] UNIV ESSEN GESAMTHSCH,SCH MED,W GERMAN CANC RES CTR,DEPT MOLEC ONCOL CANC RES,W-4300 ESSEN 1,GERMANY
关键词
D O I
10.1006/geno.1995.1057
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The common fragile site at 3p14.2 (FRA3B) has been described as the most active fragile site in the human genome. This locus may predispose chromosome 3 to specific losses due to deletions and translocations that have been associated with several malignancies, including hereditary renal cell carcinoma. We have previously described induction of breakage around FRA3B using aphidicolin in a somatic cell hybrid whose only human component was a single intact chromosome 3. That work led to the isolation of hybrids with breakpoints in the 3p13-p21.1 region with loss of all sequences distal to their respective breakpoints. In this report we describe the further characterization of the breakpoints in many of these cell lines using newly available molecular markers. We also report the identification of YAC clones that span the breakpoints present in many of these hybrids. (C) 1995 Academic Press Inc.
引用
收藏
页码:358 / 361
页数:4
相关论文
共 23 条
[1]  
ABURATANI H, 1995, CYTOGENET CELL GENET, V68, P125
[2]   CHARACTERIZATION OF A MICRODISSECTION LIBRARY FROM HUMAN-CHROMOSOME REGION 3P14 [J].
BARDENHEUER, W ;
SZYMANSKI, S ;
LUX, A ;
LUDECKE, HJ ;
HORSTHEMKE, B ;
CLAUSSEN, U ;
SENGER, G ;
SMITH, DI ;
WANG, ND ;
LEPASLIER, D ;
COHEN, D ;
HEPPELLPARTON, A ;
RABBITTS, P ;
SCHUTTE, J ;
OPALKA, B .
GENOMICS, 1994, 19 (02) :291-297
[3]   REPORT OF THE COMMITTEE ON CHROMOSOME REARRANGEMENTS IN NEOPLASIA AND ON FRAGILE SITES [J].
BERGER, R ;
BLOOMFIELD, CD ;
SUTHERLAND, GR .
CYTOGENETICS AND CELL GENETICS, 1985, 40 (1-4) :490-535
[4]   POSITIONAL CLONING OF THE HEREDITARY RENAL-CARCINOMA 3-8 CHROMOSOME-TRANSLOCATION BREAKPOINT [J].
BOLDOG, FL ;
GEMMILL, RM ;
WILKE, CM ;
GLOVER, TW ;
NILSSON, AS ;
CHANDRASEKHARAPPA, SC ;
BROWN, RS ;
LI, FP ;
DRABKIN, HA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (18) :8509-8513
[5]   HEREDITARY RENAL-CELL CARCINOMA ASSOCIATED WITH A CHROMOSOMAL TRANSLOCATION [J].
COHEN, AJ ;
LI, FP ;
BERG, S ;
MARCHETTO, DJ ;
TSAI, S ;
JACOBS, SC ;
BROWN, RS .
NEW ENGLAND JOURNAL OF MEDICINE, 1979, 301 (11) :592-595
[6]   AN UNUSUALLY PROXIMAL DELETION ON THE SHORT ARM OF CHROMOSOME 3 IN A PATIENT WITH SMALL-CELL LUNG-CANCER [J].
DALY, MC ;
DOUGLAS, JB ;
BLEEHEN, NM ;
HASTLETON, P ;
TWENTYMAN, PR ;
SUNDARESAN, V ;
CARRITT, B ;
BERGH, J ;
RABBITTS, PH .
GENOMICS, 1991, 9 (01) :113-119
[7]   DEVELOPMENT OF A SOMATIC-CELL HYBRID MAPPING PANEL AND MOLECULAR PROBES FOR HUMAN CHROMOSOME-3 [J].
DRABKIN, H ;
WRIGHT, M ;
JONSEN, M ;
VARKONY, T ;
JONES, C ;
SAGE, M ;
GOLD, S ;
MORSE, H ;
MENDEZ, M ;
ERICKSON, P .
GENOMICS, 1990, 8 (03) :435-446
[8]   TRANSLOCATION OF C-MYC IN THE HEREDITARY RENAL-CELL CARCINOMA ASSOCIATED WITH A T(3-8)(P14.2-Q24.13) CHROMOSOMAL TRANSLOCATION [J].
DRABKIN, HA ;
BRADLEY, C ;
HART, I ;
BLESKAN, J ;
LI, FP ;
PATTERSON, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :6980-6984
[9]  
GEMMILL RM, 1995, CYTOGENET CELL GENET, V68, P125
[10]   DNA POLYMERASE-ALPHA INHIBITION BY APHIDICOLIN INDUCES GAPS AND BREAKS AT COMMON FRAGILE SITES IN HUMAN-CHROMOSOMES [J].
GLOVER, TW ;
BERGER, C ;
COYLE, J ;
ECHO, B .
HUMAN GENETICS, 1984, 67 (02) :136-142