PROBLEM OF BETWEEN-EYE CORRELATION FOR STATISTICAL HYPOTHESIS-TESTING - RABBIT CORNEAL THICKNESS

被引:18
作者
BARBEITO, R [1 ]
HERSE, PR [1 ]
机构
[1] UNIV HOUSTON,COLL OPTOMETRY,HOUSTON,TX 77004
关键词
STATISTICS; BETWEEN-EYE CORRELATION; CORNEAL THICKNESS;
D O I
10.1097/00006324-199101000-00011
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The two eyes of a subject often yield correlated data. Statistical analysis which treats correlated data as if it were independent is most likely to be biased toward statistical significance; that is, the probability of a type I error is likely to be inflated. To illustrate the importance of lack of independence to the inferential process, data from an experimental design commonly used in optometric research are used to demonstrate (1) the potential magnitude of between-eye correlation, (2) the statistical bias toward a significant outcome when the between-eye correlations is ignored via inappropriate analysis, and (3) simple ways by which the bias can be avoided. The researcher must be aware of the between-eye correlation which exists for the particular effect under study, and the statistical bias that ensues from the correlation when the data are not handled correctly.
引用
收藏
页码:73 / 76
页数:4
相关论文
共 15 条
[1]  
Hays W.L., Statistics, (1988)
[2]  
Kahn H.A., Letter, Invest Ophthalmol Vis Sci, 13, pp. 634-635, (1974)
[3]  
Newcombe R.G., Duff G.R., Eyes or patients? Traps for the unwary in statistical analysis of ophthalmological studies, Br J Ophthalmol, 71, pp. 645-646, (1987)
[4]  
Armaly M.F., On the distribution of applanation pressure. I. Statistical features and the effect of age, sex, and family history of glaucoma, Arch Ophthalmol, 73, pp. 11-18, (1965)
[5]  
Alsbirk P.H., Corneal thickness. 1. Age variation. Sex differences and oculometric correlations, Acta Ophthalmol (Kbh), 56, pp. 95-104, (1978)
[6]  
Hansen F.K., A clinical study of the normal human central corneal thickness, Acta Ophthalmol (Kbh), 49, pp. 82-89, (1971)
[7]  
Rosner B., Statistical methods in ophthalmology: An adjustment for the intraclass correlation between eyes, Biometrics, 38, pp. 105-114, (1982)
[8]  
Ray W.A., O'Day D.M., Head W.S., Robinson R., Statistical analysis for experimental models of ocular disease: Continuous response measures, Curr Eye Res, 4, pp. 585-597, (1985)
[9]  
Ederer F., Shall we count numbers of eyes or numbers of subjects?, Arch Ophthalmol, 89, pp. 1-2, (1973)
[10]  
Katz J., Sommer A., Comment on eyes or patients. Traps for the unwary In the statistical analysis of ophthalmological studies, Surv Ophthalmol, 33, (1988)