A STUDY OF PERIPHERAL DIABETIC NEUROPATHY - THE APPLICATION OF AGE-RELATED REFERENCE VALUES

被引:53
作者
ARMSTRONG, FM
BRADBURY, JE
ELLIS, SH
OWENS, DR
ROSEN, I
SONKSEN, P
SUNDKVIST, G
机构
[1] Medical Research Department, Ici Pharmaceuticals Plc, Macclesfield
[2] Diabetic Research Unit, Department of Medicine, University of Wales, Cardiff
[3] Department of Clinical Neurophysiology, University Hospital, Lund
[4] Department of Medicine, St Thomas' Hospital Medical School, London
[5] Department of Medicine, University of Lund, Malmo
关键词
NEUROPATHY; DIABETES MELLITUS; DIABETIC COMPLICATIONS; METHODOLOGY; ALDOSE-REDUCTASE INHIBITORS;
D O I
10.1111/j.1464-5491.1991.tb02166.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The standardization of methodology and the provision of age-related reference values have been addressed for the design of and interpretation of data from a multicentre neuropathy trial. Age-related reference values were generated from 120 healthy volunteers. Vibration perception thresholds (VPT) deteriorated significantly with age (p < 0.001). Patients were selected on the basis of age-related abnormal VPT and peroneal motor nerve conduction velocity. They were assessed at the beginning and end of a placebo run-in period (baseline data). The coefficients of variation (CV %) for VPT at the medial malleolus (16.81 per cent, n = 316) and great toe (19.23 per cent, n = 313) were lower compared to results in healthy volunteers (29.7 per cent and 20.8 per cent, respectively, n = 49). The CV % for expiratory:inspiratory (E:I) ratio (4.82 per cent, n = 215), Valsalva manoeuvre (10.84 per cent, n = 249) and 30:15 ratio (7.73 per cent, n = 292) from patients corresponded to those recorded in volunteers (7.6 per cent, n = 45 11.0 per cent, n = 49 9.5 per cent, n = 48, respectively). Most patient values for VPT at the great toe fell beyond the 95 centile line for volunteers. E:I ratio for volunteers showed a more variable relationship with age, although patient values appeared to be located below the 5 centile line for volunteer data.
引用
收藏
页码:S94 / S99
页数:6
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