ACTIONS OF ENDOTHELIN-1 ON PROSTAGLANDIN PRODUCTION BY GESTATIONAL TISSUES

被引：31

作者：

MITCHELL, MD ^{[1
]}

ROMERO, RJ ^{[1
]}

LEPERA, R ^{[1
]}

RITTENHOUSE, L ^{[1
]}

EDWIN, SS ^{[1
]}

机构：

[1] YALE UNIV,DEPT OBSTET & GYNECOL,NEW HAVEN,CT 06520

来源：

PROSTAGLANDINS | 1990年 / 40卷 / 06期

关键词：

D O I：

10.1016/0090-6980(90)90007-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelin-1 (10(-11)M-10(-7)M) was incubated with human umbilical vein endothelial cells and cells derived from amnion and decidua and prostaglandin production was determined. The rates of biosynthesis of 6-keto-prostaglandin F1-alpha (6-keto-PGF1-alpha) and prostaglandin E2 (PGE2) by endothelial cells were increased significantly by treatment with endothelin-1. Amnion cell PGE2 production was reduced significantly by endothelin-1 treatment whereas decidual PGE2 and prostaglandin F2-alpha production was unaffected by this treatment. Thus, it is possible that endothelins may play a part in the regulation of uteroplacental hemodynamics and the mechanisms of parturition.

引用

页码：627 / 635

页数：9

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