3-DIMENSIONAL STRUCTURAL RESEMBLANCE BETWEEN LEUCINE AMINOPEPTIDASE AND CARBOXYPEPTIDASE-A REVEALED BY GRAPH-THEORETICAL TECHNIQUES

被引：38

作者：

ARTYMIUK, PJ ^{[1
]}

GRINDLEY, HM ^{[1
]}

PARK, JE ^{[1
]}

RICE, DW ^{[1
]}

WILLETT, P ^{[1
]}

机构：

[1] UNIV SHEFFIELD,DEPT INFORMAT STUDIES,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

来源：

FEBS LETTERS | 1992年 / 303卷 / 01期

基金：

英国惠康基金;

关键词：

STRUCTURAL SIMILARITY; GRAPH THEORY; CARBOXYPEPTIDASE; AMINOPEPTIDASE; PROTEIN EVOLUTION;

D O I：

10.1016/0014-5793(92)80475-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using 3-D searching techniques based on algorithms derived from graph theory we have established a striking structural similarity between the structure of bovine carboxypeptidase A and that of the C-terminal domain of bovine leucine aminopeptidase. There is no significant sequence homology between the aminopeptidases and the carboxypeptidases but the strong structural relationship detected in this complex fold suggests that there may be a very remote divergent evolutionary relationship between these two enzyme classes.

引用

页码：48 / 52

页数：5

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