THE B-CELL ANTIGEN CD75 IS A CELL-SURFACE SIALYLTRANSFERASE

被引：66

作者：

STAMENKOVIC, I

ASHEIM, HC

DEGGERDAL, A

BLOMHOFF, HK

SMELAND, EB

FUNDERUD, S

机构：

[1] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[2] MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114

[3] NORWEGIAN RADIUM HOSP,INST CANC RES,IMMUNOL LAB,N-0310 OSLO 3,NORWAY

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 172卷 / 02期

关键词：

D O I：

10.1084/jem.172.2.641

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this work we have isolated a cDNA clone encoding the B cell antigen CD75. The amino acid sequence of CD75 is shown to be identical to that of human α2,6 sialyltransferase, believed to be primarily associated with the Golgi complex. This is the first demonstration ofcell surface expression of sialyltransferase which, in B cells, may play an important role in intercellular adhesion and antigen presentation events. © 1990, Rockefeller University Press., All rights reserved.

引用

收藏

页码：641 / 643

页数：3

相关论文

共 22 条

[1] A NONRADIOACTIVE AUTOMATED-METHOD FOR DNA-SEQUENCE DETERMINATION [J].

ANSORGE, W ;

SPROAT, BS ;

STEGEMANN, J ;

SCHWAGER, C .

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 1986, 13 (06) :315-323

[2] AUTOMATED DNA SEQUENCING - ULTRASENSITIVE DETECTION OF FLUORESCENT BANDS DURING ELECTROPHORESIS [J].

ANSORGE, W ;

SPROAT, B ;

STEGEMANN, J ;

SCHWAGER, C ;

ZENKE, M .

NUCLEIC ACIDS RESEARCH, 1987, 15 (11) :4593-4602

[3] MOLECULAR-CLONING OF A CD28 CDNA BY A HIGH-EFFICIENCY COS CELL EXPRESSION SYSTEM [J].

ARUFFO, A ;

SEED, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) :8573-8577

[4]

AUFFRAY C, 1980, EUR J BIOCHEM, V107, P303

[5] CYCLIC AMP-MEDIATED SUPPRESSION OF NORMAL AND NEOPLASTIC B-CELL PROLIFERATION IS ASSOCIATED WITH REGULATION OF MYC AND HA-RAS PROTOONCOGENES [J].

BLOMHOFF, HK ;

SMELAND, EB ;

BEISKE, K ;

BLOMHOFF, R ;

RUUD, E ;

BJORO, T ;

PFEIFEROHLSSON, S ;

WATT, R ;

FUNDERUD, S ;

GODAL, T ;

OHLSSON, R .

JOURNAL OF CELLULAR PHYSIOLOGY, 1987, 131 (03) :426-433

[6]

DORKEN B, 1989, LEUCOCYTE TYPING, V4, P109

[7] CELL-ADHESION AND THE MOLECULAR PROCESSES OF MORPHOGENESIS [J].

EDELMAN, GM .

ANNUAL REVIEW OF BIOCHEMISTRY, 1985, 54 :135-169

[8]

ERIKSTEIN BK, 1989, LEUCOCYTE TYPING, V4, P110

[9] COMPLETE CDNA SEQUENCE ENCODING HUMAN BETA-GALACTOSIDE ALPHA-2,6-SIALYTRANSFERASE [J].

GRUNDMANN, U ;

NERLICH, C ;

REIN, T ;

ZETTLMEISSL, G .

NUCLEIC ACIDS RESEARCH, 1990, 18 (03) :667-667

[10] COMPILATION AND ANALYSIS OF SEQUENCES UPSTREAM FROM THE TRANSLATIONAL START SITE IN EUKARYOTIC MESSENGER-RNAS [J].

KOZAK, M .

NUCLEIC ACIDS RESEARCH, 1984, 12 (02) :857-872