THE ANTITUMOR EFFECT OF A SMALL POLYPEPTIDE FROM CORIOLUS-VERSICOLOR (SPCV)

被引：28

作者：

YANG, MMP

CHEN, Z

KWOK, JSL

机构：

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 1992年 / 20卷 / 3-4期

关键词：

D O I：

10.1142/S0192415X92000230

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

A new small polypeptide was isolated from the crude extraction of polysaccharide peptide of Coriolus versicolor (Cov-1) by HPLC and CIEF. It has a smaller molecular weight (10K) compared with that of PSP (100K) and was named small peptide of Coriolus versicolor, SPCV. It was found that SPCV possesses potent cytotoxic effect on human tumor cell lines of HL-60, LS 174-T, SMMU-7721, and SCG-7901. The IC50 of SPCV on HL-60 was 30 mug/ml. The inhibition rates of leukemia cells and SCG-7901 were significantly higher in SPCV treated group than that in PSP and PSK groups. SPCV also has immunopotentiating effect as it increased WBC and IgG levels. Pretreatment of SPCV for two weeks decreased the incidence of tumor mass in nude mice inoculated with tumor cells.

引用

页码：221 / 232

页数：12