MULTIVARIATE GENETIC-ANALYSIS OF APO-AI CONCENTRATION AND HDL SUBFRACTIONS - EVIDENCE FOR MAJOR LOCUS PLEIOTROPY

被引：20

作者：

BLANGERO, J

WILLIAMSBLANGERO, S

MAHANEY, MC

机构：

[1] Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas

来源：

GENETIC EPIDEMIOLOGY | 1993年 / 10卷 / 06期

关键词：

MULTIVARIATE SEGREGATION ANALYSIS; QUANTITATIVE TRAITS; STATISTICAL GENETICS;

D O I：

10.1002/gepi.1370100648

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A major locus influencing apolipoprotein Al (apo AI) serum levels was detected using data from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic variability in apo AI levels. Multivariate segregation analysis revealed that this major locus also has significant pleiotropic effects on the relative distribution of high density lipoproteins. (C) 1993 Wiley-Liss, Inc.

引用

页码：617 / 622

页数：6

共 6 条

[1]

AITCHISON J, 1986, STATISTICAL ANAL COM

[2]

BALANGERO J, 1991, GENET EPIDEMIOL, V8, P299

[3]

BLANGERO J, 1990, AM J HUM GENET, V47, P414

[4] A MIXED-MODEL LIKELIHOOD APPROXIMATION ON LARGE PEDIGREES [J].

HASSTEDT, SJ .

COMPUTERS AND BIOMEDICAL RESEARCH, 1982, 15 (03) :295-307

[5]

HASSTEDT SJ, 1989, PEDIGREE ANAL PACKAG

[6] ASSOCIATIONS OF LIPOPROTEINS AND APOLIPOPROTEINS WITH GRADIENT GEL-ELECTROPHORESIS ESTIMATES OF HIGH-DENSITY-LIPOPROTEIN SUBFRACTIONS IN MEN AND WOMEN [J].

WILLIAMS, PT ;

KRAUSS, RM ;

VRANIZAN, KM ;

STEFANICK, ML ;

WOOD, PDS ;

LINDGREN, FT .

ARTERIOSCLEROSIS AND THROMBOSIS, 1992, 12 (03) :332-340

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