MULTIPLE-SCLEROSIS - GENETIC VERSUS ENVIRONMENTAL ETIOLOGY - EPIDEMIOLOGY IN ISRAEL UPDATED

被引:42
作者
KAHANA, E
ZILBER, N
ABRAMSON, JH
BITON, V
LEIBOWITZ, Y
ABRAMSKY, O
机构
[1] HADASSAH HEBREW UNIV HOSP,DEPT NEUROL,JERUSALEM,ISRAEL
[2] HEBREW UNIV JERUSALEM,HADASSAH SCH PUBL HLTH & COMMUNITY MED,DEPT SOCIAL MED,JERUSALEM,ISRAEL
[3] CNRS,PIREN,F-75005 PARIS,FRANCE
[4] FRANCE RES CTR JERUSALEM,JERUSALEM,ISRAEL
关键词
MULTIPLE SCLEROSIS EPIDEMIOLOGY; IMMIGRANTS ENVIRONMENT; GENETICS;
D O I
10.1007/BF00868444
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The incidence and prevalence of multiple sclerosis (MS) were compared, controlling for age, in native-born Israelis of different origins and in immigrants to Israel. This comparison was carried out in two populations, countrywide and in Jerusalem. In the countrywide population, ascertainment was based mainly on hospitalizations; it included 252 patients who were native-born and 150 who had immigrated from Africa-Asia (AA immigrants). The 89 MS patients of Jerusalem also included patients diagnosed in outpatient clinics. In native-born Israelis whose father was born in Europe-America (I-EA), the incidence and prevalence of MS were found to be as high as or even higher than that found previously in immigrants from Europe-America. Among native-born Israelis whose father was born in Africa or Asia (I-AA), the yearly age-adjusted incidence and prevalence rates were found to be 1.4- to 1.8-fold higher than among AA immigrants, pointing to environmental factors. The incidence and prevalence rates in the I-EA were 1.2- to 1.6-fold higher than in the I-AA, pointing to genetic factors. These results seem to point to both environmental and genetic factors in the aetiology of MS. Further research is needed, however, to disentangle the genetic factors from possible environmental differences in the two ethnic groups.
引用
收藏
页码:341 / 346
页数:6
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