APPLICATION OF VOLUME-SELECTED, 2-DIMENSIONAL MULTIPLE-QUANTUM EDITING INVIVO TO OBSERVE CEREBRAL METABOLITES

The volume selection technique SPACE has been combined with a two‐dimensional multiple‐quantum editing sequence to uniquely detect certain J‐coupled cerebral metabolites. In vivo results demonstrating edited glutamate/glutamine and lactate from 0.4 ml of a rat's brain at 4.7 T are presented. The sequence was optimized to balance multiple‐quantum generation and signal loss due to T2 relaxation. Without due regard to T2 relaxation little signal is observed. © 1990 Academic Press, Inc. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company