PROTECTIVE ACTION OF PHOSPHATIDYLSERINE ON STRESS-INDUCED BEHAVIORAL AND AUTONOMIC CHANGES IN AGED RATS

被引：7

作者：

DRAGO, F ^{[1
]}

SPADARO, F ^{[1
]}

DAGATA, V ^{[1
]}

VALERIO, C ^{[1
]}

GRASSI, M ^{[1
]}

MAUCERI, F ^{[1
]}

PENNISI, G ^{[1
]}

SCAPAGNINI, U ^{[1
]}

机构：

[1] UNIV CATANIA, SCH MED, INST NEUROL CLIN, I-95125 CATANIA, ITALY

来源：

NEUROBIOLOGY OF AGING | 1991年 / 12卷 / 05期

关键词：

PHOSPHATIDYLSERINE; STRESS; AGING; GROOMING; HYPERTHERMIA; GASTRIC ULCERS;

D O I：

10.1016/0197-4580(91)90070-Z

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Phosphatidylserine (PS) was administered in aged rats subjected to various stressor stimuli in order to evaluate its effect on grooming behavior, core temperature and gastric ulcers. Novelty-induced grooming appeared to be increased in aged rats as compared to young controls. The subchronic intraperitoneal treatment with PS (20 mg/kg/day for 20 days) decreased grooming activity in aged rats, whereas it did not affect that of young animals. Restraint stress induced hyperthermia in both aged and young rats. However, 90 min after the beginning of restraint, PS-treated old rats showed a normalization of core temperature. Furthermore, restraint-plus-cold stress induced gastric ulcers in both aged and young rats. The treatment with PS was followed by a decreased incidence of gastric lesions in aged, but not in young rats. The mechanism of PS protective action against stress-induced behavioral and autonomic changes is unknown, but it may involve the brain level as this drug exerts a noteworthy influence on behavior and autonomic functions.

引用

页码：437 / 440

页数：4

共 39 条

[1] AGE-DEPENDENT SPONTANEOUS EEG BURSTS IN RATS - EFFECTS OF BRAIN PHOSPHATIDYLSERINE [J].