MOLECULAR-CLONING AND COMPLETE NUCLEOTIDE-SEQUENCE OF GENOMIC RNA OF THE AIK-C-STRAIN OF ATTENUATED MEASLES-VIRUS

被引：44

作者：

MORI, T ^{[1
]}

SASAKI, K ^{[1
]}

HASHIMOTO, H ^{[1
]}

MAKINO, S ^{[1
]}

机构：

[1] KITASATO INST,DEPT VIROL,SHIROKANE 5-9-1,MINATO KU,TOKYO 108,JAPAN

来源：

VIRUS GENES | 1993年 / 7卷 / 01期

关键词：

MEASLES VIRUS; MEASLES VACCINE; ATTENUATED STRAIN; MOLECULAR CLONING; GENOME SEQUENCE;

D O I：

10.1007/BF01702349

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Twelve cDNA clones covering the entire genome of the AIK-C strain of a seed for live measles vaccine were obtained, and the nucleotide sequences were determined. The full viral genomic RNA consists of 15,894 nucleotides. Comparisons of the nucleotide sequence and the deduced amino acid sequence between the AIK-C and other Edmonston strains revealed the following changes: 56 nucleotide differences and one C residue insertion, 31 amino acid changes, and 19 silent mutations.

引用

页码：67 / 81

页数：15

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