(-)DEPRENYL INCREASES ACTIVITIES OF SUPEROXIDE-DISMUTASE (SOD) IN STRIATUM OF DOG BRAIN

被引：34

作者：

CARRILLO, MC

IVY, GO

MILGRAM, NW

HEAD, E

WU, P

KITANI, K

机构：

[1] UNIV TOKYO,FAC MED,RADIOISOTOPE RES INST,BUNKYO KU,TOKYO 113,JAPAN

[2] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT CLIN PHYSIOL,ITABASHI KU,TOKYO,JAPAN

[3] UNIV TORONTO,DIV LIFE SCI,SCARBOROUGH M1C 1A4,ON,CANADA

[4] UNIV TORONTO,DEPT PHYSIOL,TORONTO,ON,CANADA

来源：

LIFE SCIENCES | 1994年 / 54卷 / 20期

关键词：

(-)DEPRENYL; SUPEROXIDE DISMUTASE; CATALASE; STRIATUM; HIPPOCAMPUS;

D O I：

10.1016/0024-3205(94)90015-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Seven beagle dogs were administered sucrose (control animals) or different doses of (-)deprenyl orally by means of capsules for 3 weeks. Activities of Cu Zn-SOD and Mn-SOD were determined in striatum and hippocampus in these animals. There was a significant dose-dependent increase in activities of total as well as in both types of SOD enzymes in striatum but not in hippocampus. The results suggest that the monoamine oxidase B inhibitor can increase antioxidant enzyme activities in striatum but not in hippocampus in the dog, thus showing brain region selectivity. These results are in accordance with previously published observations in rats.

引用

页码：1483 / 1489

页数：7

共 16 条

[1] INCREASED LIFE EXPECTANCY RESULTING FROM ADDITION OF L-DEPRENYL TO MADOPAR TREATMENT IN PARKINSONS-DISEASE - A LONGTERM STUDY [J].