SITES OF ACCUMULATION OF THE ANTITUMOR ALKALOID CAMPTOTHECIN IN CAMPTOTHECA-ACUMINATA

被引：88

作者：

LOPEZMEYER, M ^{[1
]}

NESSLER, CL ^{[1
]}

MCKNIGHT, TD ^{[1
]}

机构：

[1] TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843

来源：

PLANTA MEDICA | 1994年 / 60卷 / 06期

关键词：

CAMPTOTHECIN; 10-HYDROXYCAMPTOTHECIN; CAMPTOTHECA ACUMINATA; NYSSACEAE; INDOLE ALKALOIDS;

D O I：

10.1055/s-2006-959571

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Camptothecin is an anticancer and antiviral alkaloid produced by the Chinese tree Camptotheca acuminata (Nyssaceae). Despite previous reports of low levels of anticancer activity in leaves of Camptotheca acuminata, we have discovered that camptothecin accumulates to approximately 0.4% of the dry weight of young leaves. This level is 1.5-fold higher than that of the seeds and 2.5-fold higher than that of the bark, the two currently used sources of the drug. As the leaves mature, the concentration and absolute amount of camptothecin decreases rapidly. The high levels of canaptothecin in young leaves could provide an easily harvested, non-destructive source of this important drug.

引用

页码：558 / 560

页数：3

共 16 条

[1] EXPRESSION OF A 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE GENE FROM CAMPTOTHECA-ACUMINATA IS DIFFERENTIALLY REGULATED BY WOUNDING AND METHYL JASMONATE [J].