ROLE OF DNA METHYLATION IN THE REGULATION OF TRANSCRIPTION

被引：277

作者：

EDEN, S

CEDAR, H

机构：

[1] Department of Cellular Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-437X(05)80052-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA methylation plays an important role in the regulation of gene expression during development. Methyl moieties at CpG residues suppress transcription by affecting DNA-protein interactions, thus altering the accessibility of genes to trans-acting factors in the cell. Because it works in cis,this mechanism is important in the control of X inactivation and genomic imprinting.

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页码：255 / 259

页数：5

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