THE COMPLEX BETWEEN CARBOXYPEPTIDASE-A AND A POSSIBLE TRANSITION-STATE ANALOG - MECHANISTIC INFERENCES FROM HIGH-RESOLUTION X-RAY STRUCTURES OF ENZYME-INHIBITOR COMPLEXES

被引：88

作者：

CHRISTIANSON, DW ^{[1
]}

LIPSCOMB, WN ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT CHEM,GIBBS CHEM LABS,CAMBRIDGE,MA 02138

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1986年 / 108卷 / 16期

关键词：

D O I：

10.1021/ja00276a048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：4998 / 5003

页数：6

共 44 条

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[3] H-1-NMR STUDY OF COBALT(II)-SUBSTITUTED CARBOXYPEPTIDASE-A
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[4] BOLOGNESI MC, 1979, J BIOL CHEM, V254, P634
[5] STRUCTURE OF THE COMPLEX BETWEEN AN UNEXPECTEDLY HYDROLYZED PHOSPHONAMIDATE INHIBITOR AND CARBOXYPEPTIDASE-A
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LIPSCOMB, WN
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (03) : 545 - 546
[6] BINDING OF A POSSIBLE TRANSITION-STATE ANALOG TO THE ACTIVE-SITE OF CARBOXYPEPTIDASE-A
CHRISTIANSON, DW
LIPSCOMB, WN
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) : 6840 - 6844
[7] NOVEL STRUCTURE OF THE COMPLEX BETWEEN CARBOXYPEPTIDASE-A AND A KETONIC SUBSTRATE-ANALOG
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LIPSCOMB, WN
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (26) : 8281 - 8283
[8] Ferscht A., 1977, ENZYME STRUCTURE MEC
[9] INHIBITION OF CARBOXYPEPTIDASE-A BY ALDEHYDE AND KETONE SUBSTRATE-ANALOGS
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[J]. BIOCHEMISTRY, 1984, 23 (09) : 2083 - 2087
[10] SITE-DIRECTED MUTAGENESIS SHOWS THAT TYROSINE 248 OF CARBOXYPEPTIDASE-A DOES NOT PLAY A CRUCIAL ROLE IN CATALYSIS
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CRAIK, CS
HILVERT, D
URDEA, MS
RUTTER, WJ
[J]. NATURE, 1985, 317 (6037) : 551 - 555

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