SEROTONIN (5-HT2) RECEPTOR-MEDIATED ENHANCEMENT OF CORTICAL UNIT-ACTIVITY

被引:29
作者
NEUMAN, RS
ZEBROWSKA, G
机构
[1] Faculty of Medicine, Memorial University, St. John's
关键词
NEOCORTEX; SEROTONIN ANTAGONISTS; UNIT ACTIVITY; NOXIOUS STIMULATION; DESYNCHRONIZATION;
D O I
10.1139/y92-230
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Simultaneous single-unit and intracortical activity were recorded from neocortical neurons in urethane-anaesthetized rats to investigate the role of serotonin (5-HT) in modifying cortical excitability. Units, at a depth of 775-1100 mum from the pial surface, discharged in a burst - pause pattern that was correlated with slow wave activity. Application of noxious somatic stimulation resulted in cortical desynchronization and altered the pattern of unit activity such that firing was continuous, i.e., the pauses were eliminated. Intravenous administration of the mixed 5-HT1C/5-HT2 antagonists (cinanserin, cyproheptadine, ketanserin, and ritanserin) prevented both desynchronization and the change in unit activity induced by noxious stimulation within 2.5-15 min of the injection. The basic pattern of burst - pause activity remained intact, but the number of spikes per burst was typically reduced, whereas interburst intervals were increased. Iontophoretic application of these antagonists onto cortical neurons resulted in actions similar to those observed following systemic administration. Intravenous and iontophoretic application of m-trifluomethylphenylpiperazine (5-HT1C agonist, 5-HT2 antagonist) resulted in actions indistinguishable from those observed with the above antagonists, from which we conclude 5-HT2 and not 5-HT1C receptors mediate the alteration in unit activity observed with noxious stimulation. The results are discussed with respect to an interaction between N-methyl-D-aspartate and 5-HT2 receptors leading to the enhanced unit activity observed with noxious stimulation.
引用
收藏
页码:1604 / 1609
页数:6
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