CDK INHIBITORS - ON THE THRESHOLD OF CHECKPOINTS AND DEVELOPMENT

被引：322

作者：

ELLEDGE, SJ

HARPER, JW

机构：

[1] Baylor College of Medicine, Houston

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 06期

关键词：

D O I：

10.1016/0955-0674(94)90055-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The regulation of cyclin-dependent kinases is at the heart of cell cycle control and, by inference, the control of cell proliferation. Recent advances in regulation or these kinases have uncovered a group of small proteins that bind to and inhibit them, thus preventing cell cycle progression. Linking these proteins to tumor suppressor functions has provided a much sought after connection between cancer and cell cycle control.

引用

收藏

页码：847 / 852

页数：6

相关论文

共 56 条

[1]

BROEK D, 1991, NATURE, V349, P388, DOI 10.1038/349388a0

[2] RATES OF P16(MTS1) MUTATIONS IN PRIMARY TUMORS WITH 9P LOSS [J].

CAIRNS, P ;

MAO, L ;

MERLO, A ;

LEE, DJ ;

SCHWAB, D ;

EBY, Y ;

TOKINO, K ;

VANDERRIET, P ;

BLAUGRUND, JE ;

SIDRANSKY, D .

SCIENCE, 1994, 265 (5170) :415-416

[3] FREQUENT SOMATIC MUTATIONS AND HOMOZYGOUS DELETIONS OF THE P16 (MTS1) GENE IN PANCREATIC ADENOCARCINOMA [J].

CALDAS, C ;

HAHN, SA ;

DACOSTA, LT ;

REDSTON, MS ;

SCHUTTE, M ;

SEYMOUR, AB ;

WEINSTEIN, CL ;

HRUBAN, RH ;

YEO, CJ ;

KERN, SE .

NATURE GENETICS, 1994, 8 (01) :27-32

[4] IDENTIFICATION OF A GENE NECESSARY FOR CELL-CYCLE ARREST BY A NEGATIVE GROWTH-FACTOR OF YEAST - FAR1 IS AN INHIBITOR OF A G1 CYCLIN, CLN2 [J].

CHANG, F ;

HERSKOWITZ, I .

CELL, 1990, 63 (05) :999-1011

[5] PHOSPHORYLATION OF FAR1 IN RESPONSE TO ALPHA-FACTOR - A POSSIBLE REQUIREMENT FOR CELL-CYCLE ARREST [J].

CHANG, F ;

HERSKOWITZ, I .

MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (04) :445-450

[6]

DONOVAN JD, 1994, IN PRESS GENES DEV

[7]

Draetta Giulio, 1993, Trends in Cell Biology, V3, P287, DOI 10.1016/0962-8924(93)90001-H

[8] P53-DEPENDENT INHIBITION OF CYCLIN-DEPENDENT KINASE-ACTIVITIES IN HUMAN FIBROBLASTS DURING RADIATION-INDUCED G1 ARREST [J].

DULIC, V ;

KAUFMANN, WK ;

WILSON, SJ ;

TLSTY, TD ;

LEES, E ;

HARPER, JW ;

ELLEDGE, SJ ;

REED, SI .

CELL, 1994, 76 (06) :1013-1023

[9]

ELDEIRY WS, 1994, CANCER RES, V54, P1169

[10] WAF1, A POTENTIAL MEDIATOR OF P53 TUMOR SUPPRESSION [J].

ELDEIRY, WS ;

TOKINO, T ;

VELCULESCU, VE ;

LEVY, DB ;

PARSONS, R ;

TRENT, JM ;

LIN, D ;

MERCER, WE ;

KINZLER, KW ;

VOGELSTEIN, B .

CELL, 1993, 75 (04) :817-825

← 1 2 3 4 5 6 →