IDENTIFICATION OF 2 ALLATOSTATINS FROM THE CRICKET, GRYLLUS-BIMACULATUS DEGEER (ENSIFERA, GRYLLIDAE) - ADDITIONAL MEMBERS OF A FAMILY OF NEUROPEPTIDES INHIBITING JUVENILE-HORMONE BIOSYNTHESIS

被引:116
作者
LORENZ, MW
KELLNER, R
HOFFMANN, KH
机构
[1] UNIV ULM,D-89069 ULM,GERMANY
[2] EUROPEAN MOLEC BIOL LAB,D-69012 HEIDELBERG,GERMANY
关键词
ALLATOSTATIN; JUVENILE HORMONE BIOSYNTHESIS; CORPORA ALLATA;
D O I
10.1016/0167-0115(95)00036-B
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Two peptide inhibitors of juvenile hormone biosynthesis, designated G. bimaculatus allatostatins A1 and A2, have been purified from extracts of the brain of the field cricket Glyllus bimaculatus. The primary structures of these peptides were assigned as Ala-Gln-His-Gln-Tyr-Ser-Phe-Gly-Leu-NH2 (Grb-AST Al) and Ala-Gly- Gly-Arg-Gln-Tyr-Gly-Phe-Gly-Leu-NH2 (Grb-AST A2). Each of the peptides shows C-terminal amino acid sequence similarity to cockroach allatostatins and blowfly callatostatins. The two peptides are potent inhibitors of in vitro juvenile hormone production by corpora allata from virgin females of G. bimaculatus.
引用
收藏
页码:227 / 236
页数:10
相关论文
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