HEMOCHROMATOSIS, MULTIORGAN HEMOSIDEROSIS, AND CORONARY-ARTERY DISEASE

被引:69
作者
MILLER, M
HUTCHINS, GM
机构
[1] UNIV MARYLAND,MED SYST,DIV CARDIOL,BALTIMORE,MD 21201
[2] JOHNS HOPKINS MED INST,DEPT PATHOL,DIV AUTOPSY PATHOL,BALTIMORE,MD 21205
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1994年 / 272卷 / 03期
关键词
D O I
10.1001/jama.272.3.231
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective.-To examine the prevalence of coronary artery disease (CAD) in autopsies of patients with iron-overload syndromes. Design.-Retrospective autopsy study of CAD in cases of hemochromatosis and multiorgan hemosiderosis. Setting.-Registry of nearly 48 000 autopsies performed at The Johns Hopkins Hospital between 1889 and 1992. Subjects.-One hundred twenty-three subjects were studied. In a 2:1 control-case ratio, 82 controls matched by age, race, and sex were compared with 41 cases with iron overload. Main Outcome Measure.-Severity of CAD. Results.-Pathological description of the coronary arteries were recorded as advanced or severe in 12% of iron-overload cases (n=41) (mean age, 57.6+/-13.2 years) compared with 38% of controls (n=82) (mean age, 57.0+/-13.8 years) (P=.01). The prevalence of three-vessel disease assessed by postmortem coronary arteriography was 11.1% in iron-overload cases (n=18) (mean age, 61.7+/-12.2 years) compared with 33.3% in controls (n=36) (mean age, 61.1+/-12.5 years) (P=.04). The odds ratio of CAD with iron overload was 0.18 (95% confidence interval, 0.04 to 0.73). Conclusions.-Iron overload resulting from hemochromatosis or multiorgan hemosiderosis is not associated with an increased prevalence of CAD.
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页码:231 / 233
页数:3
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