THE OPIOID PEPTIDE DYNORPHIN MEDIATES HETEROSYNAPTIC DEPRESSION OF HIPPOCAMPAL MOSSY FIBER SYNAPSES AND MODULATES LONG-TERM POTENTIATION

被引:248
作者
WEISSKOPF, MG
ZALUTSKY, RA
NICOLL, RA
机构
[1] UNIV CALIF SAN FRANCISCO, GRAD PROGRAM NEUROSCI, SAN FRANCISCO, CA 94143 USA
[2] UNIV CALIF SAN FRANCISCO, DEPT PHARMACOL, SAN FRANCISCO, CA 94143 USA
[3] UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA
关键词
D O I
10.1038/362423a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The mossy fibre pathway in the hippocampus uses glutamate as a neurotransmitter, but also contains the opioid peptide dynorphin. Synaptic release of dynorphin causes a presynaptic inhibition of neighbouring mossy fibres and inhibits the induction and expression of mossy fibre long-term potentiation. These findings demonstrate a physiological role for a neuropeptide in the central nervous system, provide a functional basis for the coexistence of a neuropeptide with classic neurotransmitters and demonstrate the very different roles played by these two classes of signalling molecules.
引用
收藏
页码:423 / 427
页数:5
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