ROLE OF GONADOTROPIN-RELEASING-HORMONE SECRETORY DYNAMICS IN THE CONTROL OF THE HUMAN MENSTRUAL-CYCLE

被引：13

作者：

FILICORI, M ^{[1
]}

COGNIGNI, G ^{[1
]}

DELLAI, P ^{[1
]}

ARNONE, R ^{[1
]}

SAMBATARO, M ^{[1
]}

FALBO, A ^{[1
]}

PECORARI, R ^{[1
]}

CARBONE, F ^{[1
]}

MERIGGIOLA, MC ^{[1
]}

机构：

[1] UNIV BOLOGNA,DEPT OBSTET & GYNAECOL,CTR REPROD ENDOCRINOL,I-40126 BOLOGNA,ITALY

来源：

HUMAN REPRODUCTION | 1993年 / 8卷

关键词：

GNRH; LH SURGE; MENSTRUAL CYCLE; OVULATION; PULSATILE;

D O I：

10.1093/humrep/8.suppl_2.62

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The pattern of episodic gonadotrophin releasing hormone (GnRH)-driven luteinizing hormone (LH) secretion changes dynamically across the human menstrual cycle. Adherence to a specific regimen of pulse amplitude and frequency is critical for normal ovulation, menstrual cyclicity and reproductive function. Derangements of episodic LH secretion are associated with anovulation. We have shown that in the human slowing of GnRH-induced LH pulses results in lower ovulatory rates and dysfunctions of the mid-cycle LH surge. This information is relevant for the understanding of the endocrine dynamics of the menstrual cycle both in normal and anovulatory subjects.

引用

页码：62 / 65

页数：4

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