MODELING OF INTERHELICAL CONTACTS IN INTERFERON-BETA, INTERFERON-GAMMA, AND DIMERIC INTERLEUKIN-5

被引：5

作者：

DENESYUK, AI ^{[1
]}

ZAVYALOV, VP ^{[1
]}

KORPELA, T ^{[1
]}

机构：

[1] UNIV TURKU,FINNISH RUSSIAN JOINT BIOTECHNOL LAB,SF-20520 TURKU,FINLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.1859

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

On the basis of crystallographic data, the alpha-helices of interferon-beta as well as each domain of interferon-gamma are located in two layers. This results in a different contribution from the amino acids placing in the middle and border alpha-helices of the layer to the hydrophobic core of the molecule. A close analysis of the structure of dimeric interleukin-5 shows related arrangements of alpha-helices. The full schemes of the interhelix contacts of interferons-beta, -gamma, and dimeric interleukin-5 were constructed. Schemes for interleukin-5 show that extension of helices correlates with the dimer topology. (C) 1994 Academic Press, Inc.

引用

页码：1401 / 1405

页数：5

共 18 条

[1] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].

BERNSTEIN, FC ;

KOETZLE, TF ;

WILLIAMS, GJB ;

MEYER, EF ;

BRICE, MD ;

RODGERS, JR ;

KENNARD, O ;

SHIMANOUCHI, T ;

TASUMI, M .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) :535-542

[2]

DENESYUK AI, 1994, UNPUB BIOCH BIOPHYS

[3] HUMAN GROWTH-HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR - CRYSTAL-STRUCTURE OF THE COMPLEX [J].

DEVOS, AM ;

ULTSCH, M ;

KOSSIAKOFF, AA .

SCIENCE, 1992, 255 (5042) :306-312

[4] NOVEL FOLD AND PUTATIVE RECEPTOR-BINDING SITE OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR [J].

DIEDERICHS, K ;

BOONE, T ;

KARPLUS, PA .

SCIENCE, 1991, 254 (5039) :1779-1782

[5] 3-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA [J].

EALICK, SE ;

COOK, WJ ;

VIJAYKUMAR, S ;

CARSON, M ;

NAGABHUSHAN, TL ;

TROTTA, PP ;

BUGG, CE .

SCIENCE, 1991, 252 (5006) :698-702

[6]

HIL CP, 1993, P NATL ACAD SCI USA, V90, P5167

[7] UNRAVELING THE STRUCTURE OF IL-2 - RESPONSE [J].

MCKAY, DB .

SCIENCE, 1992, 257 (5068) :412-413

[8] A NOVEL DIMER CONFIGURATION REVEALED BY THE CRYSTAL-STRUCTURE AT 2.4 ANGSTROM RESOLUTION OF HUMAN INTERLEUKIN-5 [J].

MILBURN, MV ;

HASSELL, AM ;

LAMBERT, MH ;

JORDAN, SR ;

PROUDFOOT, AEI ;

GRABER, P ;

WELLS, TNC .

NATURE, 1993, 363 (6425) :172-176

[9] 3-DIMENSIONAL STRUCTURE OF DIMERIC HUMAN RECOMBINANT MACROPHAGE COLONY-STIMULATING FACTOR [J].

PANDIT, J ;

BOHM, A ;

JANCARIK, J ;

HALENBECK, R ;

KOTHS, K ;

KIM, SH .

SCIENCE, 1992, 258 (5086) :1358-1362

[10] STRUCTURAL COMPARISONS AMONG THE SHORT-CHAIN HELICAL CYTOKINES [J].

ROZWARSKI, DA ;

GRONENBORN, AM ;

CLORE, GM ;

BAZAN, JF ;

BOHM, A ;

WLODAWER, A ;

HATADA, M ;

KARPLUS, PA .

STRUCTURE, 1994, 2 (03) :159-173

← 1 2 →