HEPARIN-INDUCED THROMBOCYTOPENIA AND FATAL THROMBOSIS IN A PATIENT WITH ACTIVATED PROTEIN-C RESISTANCE

被引：10

作者：

GARDYN, J

SORKIN, P

KLUGER, Y

KABILI, S

KLAUSNER, JM

ZIVELIN, A

ELDOR, A

机构：

[1] ICHILOV HOSP,TEL AVIV MED CTR,DEPT MED F & SURG BE,INST HEMATOL,RESP INTENS CARE UNIT,IL-64239 TEL AVIV,ISRAEL

[2] C SHEBA MED CTR,INST THROMBOSIS & HEMOSTASIS,TEL HASHOMER,ISRAEL

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1995年 / 50卷 / 04期

关键词：

ACTIVATED PROTEIN C RESISTANCE; HEPARIN-INDUCED THROMBOCYTOPENIA; THROMBOSIS;

D O I：

10.1002/ajh.2830500412

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 20-year-old woman who developed heparin-induced thrombocytopenia (HIT) associated with devastating and fatal multiorgan thrombosis. The patient, her mother, and her brother were found to have resistance to activated protein C (APC), and the congenital thrombophilia in this family was verified by the finding of the Arg(506) Gln mutation in factor V. This is the first case of HIT and APC resistance, The consequences of this association are discussed. (C) 1995 Wiley-Liss, Inc.

引用

页码：292 / 295

页数：4

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