DNA-SEQUENCE COMPARISON OF MICROPIA TRANSPOSABLE ELEMENTS FROM DROSOPHILA-HYDEI AND DROSOPHILA-MELANOGASTER

被引：21

作者：

LANKENAU, DH ^{[1
]}

HUIJSER, P ^{[1
]}

JANSEN, E ^{[1
]}

MIEDEMA, K ^{[1
]}

HENNIG, W ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN,DEPT MOLEC & DEV GENET,TOERNOOIVELD,6525 ED NIJMEGEN,NETHERLANDS

来源：

CHROMOSOMA | 1990年 / 99卷 / 02期

关键词：

D O I：

10.1007/BF01735326

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the retrotransposon family micropia were discovered as constituents of wild-type Y chromosomal fertility genes from Drosophila hydei. Several members of the micropia family have subsequently been recovered from Drosophila melanogaster and four micropia elements, micropia-DhMiF2, -DhMiF8, -Dm11 and-Dm2, two each from D. hydei and D. melanogaster, have been totally sequenced (17 kb of micropia sequences and 6.8 kb from insertions)1. Comparative analysis of micropia sequences revealed a complex pattern of divergence within a single Drosophila genome. The divergence includes deletions, possibly by a slipped mispairing mechanism, insertions of a retroposon, and of another retro transposon (copia) and "positional nucleotide shuffling" within the tandem repeats of the 3′ non-protein-coding region of micropia elements. A 10 bp long sequence of each repeat unit of the 3′ tandem repeats of micropia elements is highly conserved and is therefore a candidate of functional importance either in transposition events or in regulatory activity on flanking DNA sequences. © 1990 Springer-Verlag.

引用

页码：111 / 117

页数：7

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