REPEATED ADMINISTRATION OF DESMETHYLIMIPRAMINE BLOCKS THE RESERPINE-INDUCED INCREASE IN TYROSINE-HYDROXYLASE MESSENGER-RNA IN LOCUS-CERULEUS NEURONS OF THE RAT

被引：12

作者：

SCHULTZBERG, M ^{[1
]}

AUSTIN, MC ^{[1
]}

CRAWLEY, JN ^{[1
]}

PAUL, SM ^{[1
]}

机构：

[1] NIMH,CLIN NEUROSCI BRANCH,BETHESDA,MD 20892

来源：

MOLECULAR BRAIN RESEARCH | 1991年 / 10卷 / 04期

关键词：

COEXISTENCE; NORADRENALINE; GALANIN; GENE REGULATION; TRICYCLIC ANTIDEPRESSANT;

D O I：

10.1016/0169-328X(91)90089-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The levels of tyrosine hydroxylase and galanin mRNA were measured by in situ hybridization histochemistry in the rat locus coeruleus after repeated (21 days) administration of desmethylimipramine (10 mg/kg/day), of reserpine (0.25 mg/kg/day), of coadministered desmethylimipramine and reserpine, or of vehicle. Reserpine administration resulted in increased levels of both tyrosine hydroxylase and galanin mRNAs in locus coeruleus neurons as compared to vehicle-treated controls. Administration of desmethylimipramine alone failed to alter either the tyrosine hydroxylase or galanin mRNA. However, coadministration of desmethylimipramine with reserpine blocked the elevation in tyrosine hydroxylase mRNA induced by reserpine alone.

引用

页码：307 / 314

页数：8

共 33 条

[1]

AUSTIN MC, IN PRESS SYNAPSE

[2]

AXELROD J, 1960, SCIENCE, V133, P383

[3] DEVELOPMENT OF BETA-ADRENERGIC-RECEPTOR SUBSENSITIVITY BY ANTIDEPRESSANTS [J].