INHIBITION OF PROSTAGLANDIN AND LEUKOTRIENE BIOSYNTHESIS BY GINGEROLS AND DIARYLHEPTANOIDS

被引：233

作者：

KIUCHI, F ^{[1
]}

IWAKAMI, S ^{[1
]}

SHIBUYA, M ^{[1
]}

HANAOKA, F ^{[1
]}

SANKAWA, U ^{[1
]}

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 02期

关键词：

GINGEROL; DIARYLHEPTANOID; ZINGIBER-OFFICINALE; ALPINIA-OFFICINARUM; PROSTAGLANDIN; 5-LIPOXYGENASE;

D O I：

10.1248/cpb.40.387

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The rhizomes of Zingiber officinale (ginger) and Alpinia officinarum contain potent inhibitors against prostaglandin biosynthesizing enzyme (PG synthetase). Gingerols and diarylhepatanoids were identified as active compounds. Their possible mechanism of action which was deduced from the structures of active compounds indicated that the inhibitors would also be active against arachidonate 5-lipoxygenase, an enzyme of leukotriene (LT) biosynthesis. This was verified by testing their inhibitory effects on 5-lipoxygenase prepared from RBL-1 cells. A diarylheptanoid with catechol group was the most active compound against 5-lipoxygenase, while yakuchinone A was the most active against PG synthetase.

引用

页码：387 / 391

页数：5

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