DECREASED SULFHYDRYL-GROUPS OF SERUM-ALBUMIN IN CORONARY-ARTERY DISEASE

被引：43

作者：

KADOTA, K ^{[1
]}

YUI, Y ^{[1
]}

HATTORI, R ^{[1
]}

MUROHARA, Y ^{[1
]}

KAWAI, C ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT INTERNAL MED,KYOTO 606,JAPAN

来源：

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION | 1991年 / 55卷 / 10期

关键词：

SULFHYDRYL GROUPS (SH); ALBUMIN; MERCAPTALBUMIN; NORMERCAPTALBUMIN; CORONARY ARTERY DISEASE;

D O I：

10.1253/jcj.55.937

中图分类号：

N09 [自然科学史]; B [哲学、宗教];

学科分类号：

01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;

摘要：

We hypothesized that oxidative processes in myocardial tissues initiated by ischemia also cause the same kind of changes in blood proteins and lead to oxidation of sulfhydryl groups (SH). To test this hypothesis, the ratio (%MA) of mercaptalbumin to total albumin (= mercaptalbumin + nonmercaptalbumin) and the total SH contents of serum were measured in patients with coronary artery disease. There was a positive correlation between %MA and total SH contents and both values were reduced in proportion to the severity of the coronary artery disease. Furthermore, these values were lower early hours after the onset of acute myocardial infraction than 4 weeks later. These results support our hypothesis, and may provide a basis for the administration of agents which can counteract oxidative stress in order to protect myocaridum in patients with coronary artery disease.

引用

页码：937 / 941

页数：5

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