ADHERENCE TO ZIDOVUDINE (AZT) AMONG HIV-INFECTED METHADONE PATIENTS - A PILOT-STUDY OF SUPERVISED THERAPY AND DISPENSING COMPARED TO USUAL CARE

被引：77

作者：

WALL, TL ^{[1
]}

SORENSEN, JL ^{[1
]}

BATKI, SL ^{[1
]}

DELUCCHI, KL ^{[1
]}

LONDON, JA ^{[1
]}

CHESNEY, MA ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,SAN FRANCISCO GEN HOSP,SUBST ABUSE SERV,1001 POTRERO AVE,SAN FRANCISCO,CA 94110

来源：

DRUG AND ALCOHOL DEPENDENCE | 1995年 / 37卷 / 03期

关键词：

ADHERENCE; COMPLIANCE; HUMAN IMMUNODEFICIENCY VIRUS (HIV); METHADONE; SUPERVISED THERAPY; ZIDOVUDINE (AZT);

D O I：

10.1016/0376-8716(94)01080-5

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Twenty-seven HIV-infected methadone maintenance patients who demonstrated problems adhering to zidovudine (AZT) were randomly assigned to a group that received eight weeks of weekday supervised therapy and dispensing of AZT or a group that received usual care of the clinic. Adherence was assessed by self-report, erythrocyte mean corpuscular volume (MCV), Medication Event Monitoring Systems (MEMS), and pill counts. Subjects in the intervention group demonstrated significantly higher MCV levels during the intervention period than usual care subjects, with similar but non-significant trends for the three other adherence measures. MEMS percent indicated significant group differences on weekdays, but not weekend days. There were no differences at a one-month follow-up. Results suggest supervised therapy and dispensing may be an effective strategy for improving AZT adherence, but only while provided. Further research is needed to establish the effects of larger and longer lasting interventions.

引用

页码：261 / 269

页数：9

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